Postdoctoral Research Fellow, Anesthesiology
Atrium Health Wake Forest Baptist, Winston Salem, NC, United States
Department:
Wake Forest University Health Sciences - Anesthesiology
This Postdoctoral Fellow position is essential for the successful execution of a highly technical, multi‑aim translational research project focused on uncovering immune mechanisms underlying chemotherapy‑induced peripheral neuropathy (CIPN) in the context of breast cancer treatment. The proposed research integrates complex orthotopic tumor models, immune‑specific genetic manipulations, advanced neurobehavioral phenotyping, and translational pharmacologic interventions, all requiring a dedicated, full‑time postdoctoral scientist with advanced methodological and analytical expertise.
Scope of the Position and Key Functions
Responsibilities
The Postdoctoral Fellow will serve as the primary experimental lead and integrator across all three Specific Aims of the project, with responsibilities including but not limited to:
Experimental Design and Execution.
Lead and coordinate immunocompetent, orthotopic breast cancer resection models combined with adjuvant chemotherapy.
Execute complex longitudinal CIPN behavioral assays (mechanical allodynia, cold sensitivity).
Perform immune‑specific genetic and pharmacologic manipulations targeting the IRE1α XBP1 pathway.
Conduct advanced flow cytometry, FACS sorting, molecular assays (qPCR, ELISA), histology, and confocal imaging.
Mechanistic and Translational Integration.
Integrate tumor progression endpoints (recurrence, lung metastases, IVIS imaging) with neurotoxicity and immune outcomes.
Perform ex vivo co‑culture assays linking immune cell activation to neuronal injury and tumor aggressiveness.
Evaluate translational pharmacologic strategies (MKC 8866 ± paclitaxel) across multiple disease contexts.
Data Analysis, Interpretation, and Dissemination.
Analyze high‑dimensional data across behavioral, molecular, immune, and oncologic endpoints.
Prepare manuscripts, conference presentations, and progress reports for funding agencies.
Contribute to grant development supporting continuation and expansion of the research program.
Research Training and Mentorship.
Provide day‑to‑day mentorship to trainees (graduate students and research staff) in specialized techniques.
Foster cross‑disciplinary collaboration between cancer biology, immunology, neuroscience, and anesthesiology.
Our Commitment to You
Advocate Health offers a comprehensive suite of Total Rewards: benefits and well‑being programs, competitive compensation, generous retirement offerings, and programs that invest in your career development.
Compensation
Base compensation in the range $30.70–$46.05 per hour based on qualifications.
Premium pay such as shift, on‑call, and more.
Incentive pay for select positions.
Opportunity for annual increases based on performance.
Benefits and More
Paid Time Off programs.
Health and welfare benefits such as medical, dental, vision, life, and short‑ and long‑term disability.
Flexible Spending Accounts for eligible health care and dependent care expenses.
Family benefits such as adoption assistance and paid parental leave.
Defined contribution retirement plans with employer match and other financial wellness programs.
Educational Assistance Program.
Position Type:
Full time
Hours per week: 40
Benefits eligible: Yes
Pay Range:
$30.70 – $46.05 per hour
Research Fellow
#J-18808-Ljbffr
Wake Forest University Health Sciences - Anesthesiology
This Postdoctoral Fellow position is essential for the successful execution of a highly technical, multi‑aim translational research project focused on uncovering immune mechanisms underlying chemotherapy‑induced peripheral neuropathy (CIPN) in the context of breast cancer treatment. The proposed research integrates complex orthotopic tumor models, immune‑specific genetic manipulations, advanced neurobehavioral phenotyping, and translational pharmacologic interventions, all requiring a dedicated, full‑time postdoctoral scientist with advanced methodological and analytical expertise.
Scope of the Position and Key Functions
Responsibilities
The Postdoctoral Fellow will serve as the primary experimental lead and integrator across all three Specific Aims of the project, with responsibilities including but not limited to:
Experimental Design and Execution.
Lead and coordinate immunocompetent, orthotopic breast cancer resection models combined with adjuvant chemotherapy.
Execute complex longitudinal CIPN behavioral assays (mechanical allodynia, cold sensitivity).
Perform immune‑specific genetic and pharmacologic manipulations targeting the IRE1α XBP1 pathway.
Conduct advanced flow cytometry, FACS sorting, molecular assays (qPCR, ELISA), histology, and confocal imaging.
Mechanistic and Translational Integration.
Integrate tumor progression endpoints (recurrence, lung metastases, IVIS imaging) with neurotoxicity and immune outcomes.
Perform ex vivo co‑culture assays linking immune cell activation to neuronal injury and tumor aggressiveness.
Evaluate translational pharmacologic strategies (MKC 8866 ± paclitaxel) across multiple disease contexts.
Data Analysis, Interpretation, and Dissemination.
Analyze high‑dimensional data across behavioral, molecular, immune, and oncologic endpoints.
Prepare manuscripts, conference presentations, and progress reports for funding agencies.
Contribute to grant development supporting continuation and expansion of the research program.
Research Training and Mentorship.
Provide day‑to‑day mentorship to trainees (graduate students and research staff) in specialized techniques.
Foster cross‑disciplinary collaboration between cancer biology, immunology, neuroscience, and anesthesiology.
Our Commitment to You
Advocate Health offers a comprehensive suite of Total Rewards: benefits and well‑being programs, competitive compensation, generous retirement offerings, and programs that invest in your career development.
Compensation
Base compensation in the range $30.70–$46.05 per hour based on qualifications.
Premium pay such as shift, on‑call, and more.
Incentive pay for select positions.
Opportunity for annual increases based on performance.
Benefits and More
Paid Time Off programs.
Health and welfare benefits such as medical, dental, vision, life, and short‑ and long‑term disability.
Flexible Spending Accounts for eligible health care and dependent care expenses.
Family benefits such as adoption assistance and paid parental leave.
Defined contribution retirement plans with employer match and other financial wellness programs.
Educational Assistance Program.
Position Type:
Full time
Hours per week: 40
Benefits eligible: Yes
Pay Range:
$30.70 – $46.05 per hour
Research Fellow
#J-18808-Ljbffr