Associate Scientist (Conjugations) (San Carlos)
R&D Partners, San Carlos, CA, United States
The Associate Scientist will support the research and development of a novel bacterial polysaccharide conjugate vaccine. Specifically, this role will contribute to the setup, synthesis, purification, and analytical characterization of chemically modified polysaccharides and polysaccharide-protein conjugates.
This is a 12-month contract based in San Carlos, CA.
Responsibilities
Set up, optimize, and troubleshoot multi-step syntheses of protein-polysaccharide conjugates using click-chemistry and other related chemistries.
Purify polysaccharides and conjugates using a variety of methods, including dialysis, FPLC chromatography, and tangential flow filtration (TFF).
Characterize protein/polysaccharide/conjugates using different analytical methods, including SDS-PAGE gel, Western blotting, ELISA, HPLC, SEC-MALS, colorimetric and dynamic binding assays, et al.
Apply Design of Experiments (DoE) principles; design, execute, and interpret statistically modeled experiments using DoE software.
Proactively contribute scientific ideas, experimental strategies, and process improvements.
Independently review and summarize relevant scientific literature to inform experimental design.
Maintain highly organized records and Benchling entries to enable optimization and assessment of reproducibility.
Analyze, interpret, and clearly communicate experimental data, including identifying trends, anomalies, and recommending next steps.
Execute established protocols with limited oversight, demonstrating strong technical proficiency.
Support team in routine laboratory activities and instrument maintenance.
Qualifications
BS. in Chemistry, Biochemistry, or related field or a related discipline, with minimum 2 years of relevant industry experience. MS without experience; or equivalent work experience.
Strong understanding of underlying scientific concepts, process development, and analytical assay principles.
Extensive hands-on experience in purification methods such as diafiltration, depth filters, and TFF (required).
Prior hands-on experience in the conjugation process development is highly desirable.
Proficiency with common protein/polysaccharide/conjugates analytical techniques, including SDS-PAGE, Western blotting, ELISA, HPLC, and SEC-MALS, is required.
Proven track record of developing scalable processes suitable for the pharma/Biotech industry.
Experience with vaccines, carbohydrates, or protein is a plus.
Attention to detail and excellent organizational skills.
Ability to contribute to the overall lab management, including organization of vendors, service contracts, and equipment maintenance.
Demonstrated success working in a cross-functional team environment.
Strong interpersonal skills, with excellent written and verbal communication skills
Salary
$106,080-$116,480
Why Choose R&D Partners?
As an employee, you have access to a comprehensive benefits package including:
Medical insurance – PPO, HMO & HSA
Dental & Vision insurance
401k plan
Employee Assistance Program
Long-term disability
Weekly payroll
Expense reimbursement
Online timecard approval
R&D Partners is a global functional service provider and strategic staffing resource specializing in scientific, clinical research & engineering. We provide job opportunities within major pharmaceutical, biopharmaceutical, biotechnology, and medical device companies.
R&D Partners is an equal-opportunity employer.
This is a 12-month contract based in San Carlos, CA.
Responsibilities
Set up, optimize, and troubleshoot multi-step syntheses of protein-polysaccharide conjugates using click-chemistry and other related chemistries.
Purify polysaccharides and conjugates using a variety of methods, including dialysis, FPLC chromatography, and tangential flow filtration (TFF).
Characterize protein/polysaccharide/conjugates using different analytical methods, including SDS-PAGE gel, Western blotting, ELISA, HPLC, SEC-MALS, colorimetric and dynamic binding assays, et al.
Apply Design of Experiments (DoE) principles; design, execute, and interpret statistically modeled experiments using DoE software.
Proactively contribute scientific ideas, experimental strategies, and process improvements.
Independently review and summarize relevant scientific literature to inform experimental design.
Maintain highly organized records and Benchling entries to enable optimization and assessment of reproducibility.
Analyze, interpret, and clearly communicate experimental data, including identifying trends, anomalies, and recommending next steps.
Execute established protocols with limited oversight, demonstrating strong technical proficiency.
Support team in routine laboratory activities and instrument maintenance.
Qualifications
BS. in Chemistry, Biochemistry, or related field or a related discipline, with minimum 2 years of relevant industry experience. MS without experience; or equivalent work experience.
Strong understanding of underlying scientific concepts, process development, and analytical assay principles.
Extensive hands-on experience in purification methods such as diafiltration, depth filters, and TFF (required).
Prior hands-on experience in the conjugation process development is highly desirable.
Proficiency with common protein/polysaccharide/conjugates analytical techniques, including SDS-PAGE, Western blotting, ELISA, HPLC, and SEC-MALS, is required.
Proven track record of developing scalable processes suitable for the pharma/Biotech industry.
Experience with vaccines, carbohydrates, or protein is a plus.
Attention to detail and excellent organizational skills.
Ability to contribute to the overall lab management, including organization of vendors, service contracts, and equipment maintenance.
Demonstrated success working in a cross-functional team environment.
Strong interpersonal skills, with excellent written and verbal communication skills
Salary
$106,080-$116,480
Why Choose R&D Partners?
As an employee, you have access to a comprehensive benefits package including:
Medical insurance – PPO, HMO & HSA
Dental & Vision insurance
401k plan
Employee Assistance Program
Long-term disability
Weekly payroll
Expense reimbursement
Online timecard approval
R&D Partners is a global functional service provider and strategic staffing resource specializing in scientific, clinical research & engineering. We provide job opportunities within major pharmaceutical, biopharmaceutical, biotechnology, and medical device companies.
R&D Partners is an equal-opportunity employer.