Postdoctoral Fellow-MSH-12907-056
Mount Sinai Medical Center, New York, NY, United States
Description
Salary: $74,692
Department: Department of Stem Cell Biology and Regenerative Medicine; Department of Medicine
Physical work location: 1468 Madison Ave, Annenberg 25-20, New York 10029, NY
Name PI or Supervisor: Tianliang Sun, tianliang.sun@mssm.edu, +1-6465893887
Web link to Lab: http://www.tianliangsunlab.com/
Web link to Department: https://icahn.mssm.edu/about/departments/regenerative-biology
Administrative Contact: Chou, Hsin hsin.chou@mssm.edu; 212-659-9219
Responsibilities
Details of Research Project:
Dr. Hao Xiang will perform the following research projects under the mentoring of Dr. Tianliang Sun:
Mechanism of boosting of liver regeneration to reverse MASH. Combining multiomics data profiling, mouse genetics, histology, intravital imaging and organoid systems, we will systemically analyze the mechanism of inflammation resolution, lipid metabolism and fibrosis regression events upon the deletion of ZNRF3 and RNF43.
The plasticity of biliary epithelial cells during ductular reaction. We aim to dissect the cell heterogeneity of biliary epithelial cells during liver injuries and the key signaling pathways that involved in regeneration and pathogenesis via various mouse genetic and injury models and organoid cultures.
Principles of liver zonation regulation and how zonation play a role in liver diseases
Technical Duties: (include any protocols)
Mouse handling and monitoring, organoid culture, multiomicas data analysis, histology and tissue processing, IF staining, image J based cell and tissue quantification, microscope imaging in fixed tissue and in live mouse, buffer preparation and lab maintenance, genotyping PCR, data recording and analysis, presentation in meetings and work in progress.
Qualifications
Educational and other Requirements for the position: PhD degree in life science
Experience Required: Training in Biomedical Science and hands on experiments in mouse genetics, molecular and cellular biology, and biochemistry.
Goals/Outcomes of the Research Project: Discover new mechanism of liver regeneration and diseases. Publish results in top-tier peer review scientific journals.
Equal Opportunity Employer
The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.
Compensation
The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.
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Salary: $74,692
Department: Department of Stem Cell Biology and Regenerative Medicine; Department of Medicine
Physical work location: 1468 Madison Ave, Annenberg 25-20, New York 10029, NY
Name PI or Supervisor: Tianliang Sun, tianliang.sun@mssm.edu, +1-6465893887
Web link to Lab: http://www.tianliangsunlab.com/
Web link to Department: https://icahn.mssm.edu/about/departments/regenerative-biology
Administrative Contact: Chou, Hsin hsin.chou@mssm.edu; 212-659-9219
Responsibilities
Details of Research Project:
Dr. Hao Xiang will perform the following research projects under the mentoring of Dr. Tianliang Sun:
Mechanism of boosting of liver regeneration to reverse MASH. Combining multiomics data profiling, mouse genetics, histology, intravital imaging and organoid systems, we will systemically analyze the mechanism of inflammation resolution, lipid metabolism and fibrosis regression events upon the deletion of ZNRF3 and RNF43.
The plasticity of biliary epithelial cells during ductular reaction. We aim to dissect the cell heterogeneity of biliary epithelial cells during liver injuries and the key signaling pathways that involved in regeneration and pathogenesis via various mouse genetic and injury models and organoid cultures.
Principles of liver zonation regulation and how zonation play a role in liver diseases
Technical Duties: (include any protocols)
Mouse handling and monitoring, organoid culture, multiomicas data analysis, histology and tissue processing, IF staining, image J based cell and tissue quantification, microscope imaging in fixed tissue and in live mouse, buffer preparation and lab maintenance, genotyping PCR, data recording and analysis, presentation in meetings and work in progress.
Qualifications
Educational and other Requirements for the position: PhD degree in life science
Experience Required: Training in Biomedical Science and hands on experiments in mouse genetics, molecular and cellular biology, and biochemistry.
Goals/Outcomes of the Research Project: Discover new mechanism of liver regeneration and diseases. Publish results in top-tier peer review scientific journals.
Equal Opportunity Employer
The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.
Compensation
The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.
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