Senior Director, Medical, Translational and Computational Pathologist
GlaxoSmithKline, Collegeville, PA, United States
Position Summary
GSK is seeking a highly motivated Pathologist, preferably with industry experience, to provide scientific, medical, and strategic leadership across translational and computational pathology. The role bridges traditional diagnostic pathology with advanced biomarker science, digital pathology, and AI‑enabled image analytics to support tissue‑based biomarker discovery, precision medicine, and diagnostic development from first‑in‑human studies through late‑stage clinical development. The candidate will be based in Philadelphia, USA, or be willing to relocate.
Key Responsibilities
Provide timely, high‑quality pathology expertise to GSK leaders, scientists, and study teams, operating within GSK policies and regulatory frameworks.
Guide and refine clinical development strategies across oncology (primary focus), respiratory, immunology, and infectious diseases, ensuring integration of histopathology, translational research, and precision medicine.
Partner with biomarker scientists and translational research teams to enable rigorous biomarker strategies, including study selection, patient stratification, and hypothesis‑driven assay deployment.
Provide strategic and scientific oversight of clinical biomarker assay development and validation, both internally and through external laboratories and CROs.
Lead the development and deployment of innovative, clinical‑grade bioassays to support program needs, including immunohistochemistry, multiplex immunofluorescence, in situ hybridization, spatial omics, genomics, flow cytometry, and related assays.
Ensure assay performance, analytical rigor, data interpretation, and regulatory readiness.
Provide direct pathology support to clinical development and translational medicine teams across programs.
Advise on clinical trial design, execution, and governance, optimizing diagnostic inclusion/exclusion criteria, tissue collection strategies, pathology endpoints, and image/data asset generation.
Review and contribute to study protocols and key clinical documentation.
Serve as a subject matter expert in interactions with health authorities, including preparation of regulatory submissions and responses, particularly for companion diagnostics.
Drive computational pathology capabilities in collaboration with histotechnology, digital pathology, and AI/ML teams.
Lead development of fit‑for‑purpose image analysis workflows and AI‑enabled models for quantification of high‑dimensional pathology data.
Advance internal CP infrastructure, including whole‑slide imaging, QC review, metadata management, annotation strategies, and digital consensus workflows.
Enable rapid, scalable data generation to support early through late‑phase clinical programs.
Support clinical trial advisory boards and engage external key opinion leaders to inform pathology‑related endpoints and strategy.
Interface with clinical trial sites, external laboratories, CROs, and technology partners.
Provide pathology input into external technology assessments, business development opportunities, and alliance management.
Advise commercial and executive leadership on pathology, diagnostics, and biomarker‑related matters.
Take on additional responsibilities as needed to meet evolving organizational priorities.
Basic Qualifications
Medical Doctor.
Completion of formal postgraduate clinical training, clinical residency or specialty training in Pathology, Anatomic Pathology (AP) or AP/CP.
Fellowship or sub‑specialty training in one or multiple surgical pathology and/or laboratory medicine disciplines.
Minimum of 5+ years post‑training experience in research, clinical practice, or industry.
Experience with digital and computational pathology tools (e.g., HALO, Visiopharm) and strong interest in advancing CP applications.
Preferred Qualifications
Medical Doctor and PhD.
Subspecialty expertise in surgical pathology relevant to GSK priorities (e.g., gynecologic, GU, head and neck, dermatopathology, soft tissue, hematopathology, pulmonary, renal, GI/liver).
Experience in molecular pathology, genomics/NGS, flow cytometry, and/or immunopathology assay validation and clinical interpretation.
Proven ability to manage multiple programs, work effectively in matrixed teams, and communicate clearly to diverse scientific, clinical, and leadership audiences.
Demonstrated scholarly activity, hypothesis‑driven research, and/or advanced degrees (MS, MPH, PhD).
Experience in digital pathology, image analysis, AI/ML, data science, bioinformatics, or disease genetics.
Track record of regulatory engagement and/or companion diagnostics development.
Experience in laboratory leadership, quality systems, education, inspection, or CAP/RCP‑related activities.
Experience supporting clinical trials, protocol authorship, CRO interactions, and multinational matrix environments.
Benefits
Annual base salary ranges for the position are $284,625 to $474,375, based on work location within the US market. The role offers an annual bonus and eligibility to participate in GSK’s share‑based long‑term incentive program. Benefits include health care, other insurance, retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.
Equal Opportunity Statement
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
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GSK is seeking a highly motivated Pathologist, preferably with industry experience, to provide scientific, medical, and strategic leadership across translational and computational pathology. The role bridges traditional diagnostic pathology with advanced biomarker science, digital pathology, and AI‑enabled image analytics to support tissue‑based biomarker discovery, precision medicine, and diagnostic development from first‑in‑human studies through late‑stage clinical development. The candidate will be based in Philadelphia, USA, or be willing to relocate.
Key Responsibilities
Provide timely, high‑quality pathology expertise to GSK leaders, scientists, and study teams, operating within GSK policies and regulatory frameworks.
Guide and refine clinical development strategies across oncology (primary focus), respiratory, immunology, and infectious diseases, ensuring integration of histopathology, translational research, and precision medicine.
Partner with biomarker scientists and translational research teams to enable rigorous biomarker strategies, including study selection, patient stratification, and hypothesis‑driven assay deployment.
Provide strategic and scientific oversight of clinical biomarker assay development and validation, both internally and through external laboratories and CROs.
Lead the development and deployment of innovative, clinical‑grade bioassays to support program needs, including immunohistochemistry, multiplex immunofluorescence, in situ hybridization, spatial omics, genomics, flow cytometry, and related assays.
Ensure assay performance, analytical rigor, data interpretation, and regulatory readiness.
Provide direct pathology support to clinical development and translational medicine teams across programs.
Advise on clinical trial design, execution, and governance, optimizing diagnostic inclusion/exclusion criteria, tissue collection strategies, pathology endpoints, and image/data asset generation.
Review and contribute to study protocols and key clinical documentation.
Serve as a subject matter expert in interactions with health authorities, including preparation of regulatory submissions and responses, particularly for companion diagnostics.
Drive computational pathology capabilities in collaboration with histotechnology, digital pathology, and AI/ML teams.
Lead development of fit‑for‑purpose image analysis workflows and AI‑enabled models for quantification of high‑dimensional pathology data.
Advance internal CP infrastructure, including whole‑slide imaging, QC review, metadata management, annotation strategies, and digital consensus workflows.
Enable rapid, scalable data generation to support early through late‑phase clinical programs.
Support clinical trial advisory boards and engage external key opinion leaders to inform pathology‑related endpoints and strategy.
Interface with clinical trial sites, external laboratories, CROs, and technology partners.
Provide pathology input into external technology assessments, business development opportunities, and alliance management.
Advise commercial and executive leadership on pathology, diagnostics, and biomarker‑related matters.
Take on additional responsibilities as needed to meet evolving organizational priorities.
Basic Qualifications
Medical Doctor.
Completion of formal postgraduate clinical training, clinical residency or specialty training in Pathology, Anatomic Pathology (AP) or AP/CP.
Fellowship or sub‑specialty training in one or multiple surgical pathology and/or laboratory medicine disciplines.
Minimum of 5+ years post‑training experience in research, clinical practice, or industry.
Experience with digital and computational pathology tools (e.g., HALO, Visiopharm) and strong interest in advancing CP applications.
Preferred Qualifications
Medical Doctor and PhD.
Subspecialty expertise in surgical pathology relevant to GSK priorities (e.g., gynecologic, GU, head and neck, dermatopathology, soft tissue, hematopathology, pulmonary, renal, GI/liver).
Experience in molecular pathology, genomics/NGS, flow cytometry, and/or immunopathology assay validation and clinical interpretation.
Proven ability to manage multiple programs, work effectively in matrixed teams, and communicate clearly to diverse scientific, clinical, and leadership audiences.
Demonstrated scholarly activity, hypothesis‑driven research, and/or advanced degrees (MS, MPH, PhD).
Experience in digital pathology, image analysis, AI/ML, data science, bioinformatics, or disease genetics.
Track record of regulatory engagement and/or companion diagnostics development.
Experience in laboratory leadership, quality systems, education, inspection, or CAP/RCP‑related activities.
Experience supporting clinical trials, protocol authorship, CRO interactions, and multinational matrix environments.
Benefits
Annual base salary ranges for the position are $284,625 to $474,375, based on work location within the US market. The role offers an annual bonus and eligibility to participate in GSK’s share‑based long‑term incentive program. Benefits include health care, other insurance, retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.
Equal Opportunity Statement
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
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