Development Scientist II, Analytical Development and Quality Control

- Relevant skills and experience will be listed so you know why those jobs are a match## Job DescriptionAccountabilities:* Protein Variant Enrichment and Characterization: Lead enrichment, fractionation and characterization of protein size and charge variants to define and monitor critical quality attributes, guiding process and formulation strategies.* Analytical Method Development and Optimization: Conduct studies and develop/optimize robust HPLC/UPLC, CE-SDS, icIEF and related methods to characterize biotherapeutic molecules across development stages, ensuring phase-appropriate, transferable methods.* Comparability and Stress Studies: Design and lead comparability and forced degradation programs to map degradation pathways, assess product robustness and inform lifecycle decisions.* Cross-Functional Leadership: Represent the Protein Characterization group on development teams, driving scientific problem-solving and aligning analytical strategy with program goals and timelines.* Regulatory and Documentation Excellence: Author CMC sections for regulatory filings, technical reports, protocols, SOPs and work practices; ensure data integrity and clarity that accelerates regulatory interactions.* Innovation and Technology Scouting: Evaluate emerging technologies and independently develop forward-looking protein characterization strategies that improve sensitivity, throughput and insight.* Project and People Leadership: Manage projects independently, set priorities, track commitments and mentor junior scientists to build capability and consistency in laboratory execution.Essential Skills/Experience:* BS degree with 10+ years, MS degree with 8+ years, or Ph.D. degree with 2+ years in Chemist, Biochemistry, or related field of Industry experience* Experienced in separations science (e.g., SEC, RP, IEX, HIC, CE-SDS and cIEF).* experienced in protein size and charge variants identification and product quality attribute severity assessment.* Planning and organizing skills to plan, execute, and track commitments of the laboratory and to adjust to changing priorities.* High emotional intelligence, excellent people skills, and effective communication skills.Desirable Skills/Experience:* Experience in CMC development activities and previous experience as project lead for analytical function.Experience in characterization of various biologic modalities (e.g., mAb, multi-specifics, fusion protein, enzyme). When we put unexpected teams in the same room, we ignite ambitious thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility.Join us in our unique and ambitious world.Why AstraZeneca:Here you will join curious minds who pair ground breaking science with data and digital tools to push beyond the expected.We bring together diverse perspectives—from internal teams to partners in academia and biotech—to solve hard problems faster, often by putting unexpected teams in the same room to spark new ideas. Your analytical decisions will influence program direction, speed development and, ultimately, help deliver medicines to people with serious conditions.We value ambition and kindness in equal measure, giving you the autonomy, resources and collaborative environment to learn, lead and make a meaningful, measurable impact.If you are ready to turn rigorous protein science into real-world impact, step forward and shape the quality of tomorrow’s medicines with us today!**Date Posted**24-Apr-2026**Closing Date**29-Jun-2026Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.## Get MatchedUpload your resume and see jobs that match your skills and experience### Popular Skills of Previous Hires* Biochemistry* Therapeutics* Pharmacology## Career benefits### Aligned to performanceOur approach is designed to stimulate our commercial growth, scientific advancement, collaboration and personal development.### BalancedOur benefits offering is flexible where possible, empowering you to choose the benefits that work for you.### HolisticWe aim to reward everything you do here and value you for the contributions and unique insights you'll bring.### SustainableWe build reward practices to be sustainable and affordable for the business, now and into the future.# Our PhilosophyAstraZeneca is a global, science-led, patient-focused pharmaceutical company committed to excellence in the research, development and commercialisation of prescription medicines. With approximately 90,000 people in 85 countries, our aim is simple: to unlock the power of what science can do, for people, society and the planet. From Clinical Development, Regulatory and Medical Affairs to Finance, IT, Digital, Manufacturing and Supply, the opportunities to make an impact are limitless. Our workforce reflects the diversity of the patients we serve – it is embedded in everything we do. We're at our best and most creative when we seek out different perspectives, experiences and strengths. At AstraZeneca, you'll have the chance to grow your abilities, skills and knowledge constantly in a place that never stands still. Discover why we're a great place to work and see what science — and you — can do.
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