Scientist I – Complex In Vitro Models
Allergan, Worcester, MA, United States
Job Description
We are seeking a highly motivated Scientist to join the Gastroenterology Immunology Discovery team. Together with a Senior Scientist, this position will drive the development and deployment of complex in vitro models to support AbbVie’s drug discovery efforts. This is a hands‑on and lab‑based role requiring significant cell biology expertise. The ideal candidate will have extensive experience with primary cell cultures and in‑vitro cell‑based assays in the context of autoimmune disease.
Key Responsibilities
Routine culture and maintenance of immortalized and primary cell cultures, both in standard formats as well as organoids or organ‑on‑chip formats.
Isolation of primary human cells from various sources including tissue and whole blood.
Work with a Senior Scientist to develop complex in‑vitro models that mimic the pathophysiology of immune mediated diseases with a focus on IBD.
Design, perform, and interpret in‑vitro experiments to support drug discovery and development activities. This may include mechanism of action experiments to advance target identification and validation efforts in immunology and IBD.
Conduct experiments with a high level of independence and initiative and performing tasks with minimal direct supervision for routine methods.
Independently schedule and prioritise workload to manage several tasks simultaneously.
Maintain detailed electronic documentation to ensure adherence to departmental procedures and contribute to final reports as needed.
Interact with other scientists within a matrixed environment including identifying and utilising resources outside of your own group and presenting findings to audiences with diverse backgrounds (e.g., immunologists, cell biologists, pathologists, bioengineers).
Qualifications
Bachelor’s Degree with typically 5 years of experience, or Master’s Degree with typically two years of experience.
Experience working with human tissue samples and with isolating and characterising cells such as epithelial, fibroblast, endothelial, and/or immunological (B cells, T cells, monocytes). Extensive experience with primary cell cultures and in‑vitro cell based assays.
Demonstrated proficiency in cell and molecular biological assays such as qPCR analysis, multicolour flow cytometry, FACS, ELISA/Luminex/MSD, cell proliferation/viability assays, cytotoxicity assays.
Experience in 3D tissue modelling (i.e. spheroids, organoids, commercially available organ‑on‑a‑chip platforms, microfluidics) is a plus.
Strong written and oral communication skills are important.
Ability to build relationships and work collaboratively with cross‑functional teams in a highly matrixed organisation.
Additional Information
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our short‑term incentive programmes.
Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested and determinable. The amount and availability of any bonus, commission, incentive, benefits or any other form of compensation and benefits that are allocable to a particular employer remains in the Company’s sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer / Veterans / Disabled.
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We are seeking a highly motivated Scientist to join the Gastroenterology Immunology Discovery team. Together with a Senior Scientist, this position will drive the development and deployment of complex in vitro models to support AbbVie’s drug discovery efforts. This is a hands‑on and lab‑based role requiring significant cell biology expertise. The ideal candidate will have extensive experience with primary cell cultures and in‑vitro cell‑based assays in the context of autoimmune disease.
Key Responsibilities
Routine culture and maintenance of immortalized and primary cell cultures, both in standard formats as well as organoids or organ‑on‑chip formats.
Isolation of primary human cells from various sources including tissue and whole blood.
Work with a Senior Scientist to develop complex in‑vitro models that mimic the pathophysiology of immune mediated diseases with a focus on IBD.
Design, perform, and interpret in‑vitro experiments to support drug discovery and development activities. This may include mechanism of action experiments to advance target identification and validation efforts in immunology and IBD.
Conduct experiments with a high level of independence and initiative and performing tasks with minimal direct supervision for routine methods.
Independently schedule and prioritise workload to manage several tasks simultaneously.
Maintain detailed electronic documentation to ensure adherence to departmental procedures and contribute to final reports as needed.
Interact with other scientists within a matrixed environment including identifying and utilising resources outside of your own group and presenting findings to audiences with diverse backgrounds (e.g., immunologists, cell biologists, pathologists, bioengineers).
Qualifications
Bachelor’s Degree with typically 5 years of experience, or Master’s Degree with typically two years of experience.
Experience working with human tissue samples and with isolating and characterising cells such as epithelial, fibroblast, endothelial, and/or immunological (B cells, T cells, monocytes). Extensive experience with primary cell cultures and in‑vitro cell based assays.
Demonstrated proficiency in cell and molecular biological assays such as qPCR analysis, multicolour flow cytometry, FACS, ELISA/Luminex/MSD, cell proliferation/viability assays, cytotoxicity assays.
Experience in 3D tissue modelling (i.e. spheroids, organoids, commercially available organ‑on‑a‑chip platforms, microfluidics) is a plus.
Strong written and oral communication skills are important.
Ability to build relationships and work collaboratively with cross‑functional teams in a highly matrixed organisation.
Additional Information
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our short‑term incentive programmes.
Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested and determinable. The amount and availability of any bonus, commission, incentive, benefits or any other form of compensation and benefits that are allocable to a particular employer remains in the Company’s sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer / Veterans / Disabled.
#J-18808-Ljbffr