MES Systems Manager
GlaxoSmithKline, Zebulon, NC, United States
Job Overview
We manufacture and supply reliable, high‑quality medicines and vaccines to meet patients’ needs and drive performance. Our 37 sites delivered 1.7 billion packs of medicines and 409 million vaccine doses in 2024.
We need the very best minds to help us on our journey to make more complex products and harness smart manufacturing technologies.
Responsibilities
Represent the site with central platform teams to ensure reliable MES operations, appropriate prioritization, and clear decision‑making on defects/enhancements. Serve as the primary site advocate to secure timely incident support.
Lead site incident, problem, and change management for MES (triage, root cause, and corrective/preventive actions). Own and drive CAPAs to completion with non‑negotiable due dates.
Facilitate and/or participate in rapid‑improvement workshops to improve MES‑supported processes and usability.
Lead the site MES solutions team in designing and improving eBRS workflows, configuring, testing, and deploying simple to medium‑complexity changes.
Manage site MES initiatives (upgrades, integrations, new deployments, retirements), coordinating engineering, production, quality, and IT stakeholders through requirements, testing, validation, cutover, and hyper‑care.
Ensure MES compliance, validation, and data integrity in alignment with regulations and internal standards. Maintain required documentation and act as a technical/functional SME during audits and inspections.
Coach and mentor site users and technical staff on MES best practices, training, and continuous improvement.
Provide on‑call/escalation support as required for business continuity, including evening and weekend work aligned to site schedules.
Own the site MES demand/roadmap: collect and translate user needs into requirements, support prioritization, and align to global templates.
Oversee MES user access and role management, ensuring segregation of duties and timely provisioning.
Establish and track operational performance metrics (e.g., uptime, incident trends, release quality, cycle‑time impacts) and communicate status to leadership and partners.
Manage site vendor engagements and support budget/forecast inputs for MES‑related work.
Lead and develop a small site MES solutions team, setting priorities, ensuring quality, and supporting succession planning.
Basic Qualifications
Bachelor’s degree in engineering, computer science, information systems, or related technical field, or equivalent experience.
5+ years’ experience supporting and/or managing MES in a regulated manufacturing environment.
Functional understanding of pharmaceutical manufacturing processes.
Experience with MES platforms (e.g., eBRS, Weigh & Dispense, IPC, Serialization) including design, configuration, administration, and troubleshooting.
Familiarity with electronic batch records (eBRS) solutions.
Experience with computer system validation and supporting validated systems.
Knowledge of system interfacing technologies (ERP, LIMS, historians, PLC/SCADA).
Stakeholder management and experience working across operations, quality, engineering, and IT.
Experience leading process improvement initiatives and coaching colleagues.
Experience leading a small team and/or influencing in a matrix environment.
Preferred Qualifications
Experience with MES implementations, upgrades, and lifecycle management in pharmaceutical or regulated industries.
Demonstrated experience leading system improvement cycles using Agile methodologies.
Demonstrated people leadership experience (hiring, coaching, development, performance management).
Experience managing external vendors and service contracts.
Experience with process control systems or industrial automation technologies.
Hands‑on experience with query and scripting languages or process trending tools for reporting and automation.
Advanced degree in engineering, computer science, or related field.
Equal Opportunity Employer
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
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We manufacture and supply reliable, high‑quality medicines and vaccines to meet patients’ needs and drive performance. Our 37 sites delivered 1.7 billion packs of medicines and 409 million vaccine doses in 2024.
We need the very best minds to help us on our journey to make more complex products and harness smart manufacturing technologies.
Responsibilities
Represent the site with central platform teams to ensure reliable MES operations, appropriate prioritization, and clear decision‑making on defects/enhancements. Serve as the primary site advocate to secure timely incident support.
Lead site incident, problem, and change management for MES (triage, root cause, and corrective/preventive actions). Own and drive CAPAs to completion with non‑negotiable due dates.
Facilitate and/or participate in rapid‑improvement workshops to improve MES‑supported processes and usability.
Lead the site MES solutions team in designing and improving eBRS workflows, configuring, testing, and deploying simple to medium‑complexity changes.
Manage site MES initiatives (upgrades, integrations, new deployments, retirements), coordinating engineering, production, quality, and IT stakeholders through requirements, testing, validation, cutover, and hyper‑care.
Ensure MES compliance, validation, and data integrity in alignment with regulations and internal standards. Maintain required documentation and act as a technical/functional SME during audits and inspections.
Coach and mentor site users and technical staff on MES best practices, training, and continuous improvement.
Provide on‑call/escalation support as required for business continuity, including evening and weekend work aligned to site schedules.
Own the site MES demand/roadmap: collect and translate user needs into requirements, support prioritization, and align to global templates.
Oversee MES user access and role management, ensuring segregation of duties and timely provisioning.
Establish and track operational performance metrics (e.g., uptime, incident trends, release quality, cycle‑time impacts) and communicate status to leadership and partners.
Manage site vendor engagements and support budget/forecast inputs for MES‑related work.
Lead and develop a small site MES solutions team, setting priorities, ensuring quality, and supporting succession planning.
Basic Qualifications
Bachelor’s degree in engineering, computer science, information systems, or related technical field, or equivalent experience.
5+ years’ experience supporting and/or managing MES in a regulated manufacturing environment.
Functional understanding of pharmaceutical manufacturing processes.
Experience with MES platforms (e.g., eBRS, Weigh & Dispense, IPC, Serialization) including design, configuration, administration, and troubleshooting.
Familiarity with electronic batch records (eBRS) solutions.
Experience with computer system validation and supporting validated systems.
Knowledge of system interfacing technologies (ERP, LIMS, historians, PLC/SCADA).
Stakeholder management and experience working across operations, quality, engineering, and IT.
Experience leading process improvement initiatives and coaching colleagues.
Experience leading a small team and/or influencing in a matrix environment.
Preferred Qualifications
Experience with MES implementations, upgrades, and lifecycle management in pharmaceutical or regulated industries.
Demonstrated experience leading system improvement cycles using Agile methodologies.
Demonstrated people leadership experience (hiring, coaching, development, performance management).
Experience managing external vendors and service contracts.
Experience with process control systems or industrial automation technologies.
Hands‑on experience with query and scripting languages or process trending tools for reporting and automation.
Advanced degree in engineering, computer science, or related field.
Equal Opportunity Employer
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
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