Executive Medical Director- Translational Medicine Group Leader Aging
GlaxoSmithKline, Waltham, MA, United States
Executive Medical Director - Translational Medicine Group Leader (TMGL) Aging
Lead efforts to bridge preclinical research and clinical development, ensuring the successful transition of innovative therapeutics from the laboratory to Proof of Mechanism/Clinical Activity in the clinic.
This hybrid position requires working on a GSK site a minimum of two days per week.
Key Accountabilities / Responsibilities
Provide disease-level leadership, developing causal maps of relevant pathobiology and tools/instruments that enable timely experimentation and prosecution to derisk mechanisms and programmes.
Strategic leadership for the design, execution, and management of clinical development plans and clinical trials for programmes in the Early Pipeline Unit.
Provide translational and clinical leadership in defining and executing innovative early development strategies, ensuring alignment with IEP, CDP, scientific rationale, regulatory requirements, product development plan and commercial goals.
Ensure alignment of scientific and clinical strategies with business objectives through matrix leadership of large cross‑functional teams.
Drive evaluation of therapeutic potential and clinical tractability of targets within the disease area.
Identify transformational opportunities where projects can offer significant benefits to patients.
Ensure quality, on-time, and on-budget delivery of studies and programs within a therapeutic area of EPU.
Design and implement experimental medicine studies.
Oversee risk assessment across programs and implement mitigation strategies.
Manage, mentor and coach early Clinical Development Leads.
Collaborate with cross‑functional teams with program counterparts in Advance Pipeline Unit, Commercial, Research Tech and Development organisations.
Build and maintain networks across internal and external stakeholders, including academic institutions, CROs, and regulators.
Represent GSK effectively in external collaborations and negotiations.
Anticipate challenges and proactively develop strategies to mitigate risks.
Make decisions balancing risk/benefit with clear understanding of project impact.
Lead the writing and review of study‑related documents and regulatory submissions.
Communicate confidently and effectively at all levels, internally and externally.
Champion implementation of innovative business processes and strategies to improve clinical development outcomes.
Basic Qualifications
Academic physician with clinical medical specialty registration, board certification or qualification.
Industry experience in clinical drug development.
Experience with planning clinical development for an asset and/or indication.
Pharmaceutical industry clinical research experience in Aging focused on aging biology; geroscience or age‑related diseases; and potential therapeutic areas.
Direct line management and leadership experience.
Preferred Qualifications
Specialist physician with PhD.
Proven record of creative problem‑solving in clinical trials and projects, such as deriving causal confidence from novel sources or qualifying a novel endpoint.
Experience working collaboratively with multiple stakeholders on complex projects.
Knowledge of translational medicine, clinical research methodology and principles of biostatistics to facilitate innovative and efficient designs of clinical trials and clinical development plans with clear data‑driven decision rules.
Track record of building and maintaining strong relationships with internal and external stakeholders.
Strong personal network across relevant scientific and clinical thought leaders, institutions and consortia in relevant therapy area.
Future‑looking and experimental track record, with demonstrable experience of tech‑enable solutions in biology, translation or clinical development.
Salary and Benefits
For U.S. locations (Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA) annual base salary ranges from $284,625 to $474,375. The position also offers an annual bonus and eligibility to participate in a share‑based long‑term incentive program. Benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.
Equal Employment Opportunity
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
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Lead efforts to bridge preclinical research and clinical development, ensuring the successful transition of innovative therapeutics from the laboratory to Proof of Mechanism/Clinical Activity in the clinic.
This hybrid position requires working on a GSK site a minimum of two days per week.
Key Accountabilities / Responsibilities
Provide disease-level leadership, developing causal maps of relevant pathobiology and tools/instruments that enable timely experimentation and prosecution to derisk mechanisms and programmes.
Strategic leadership for the design, execution, and management of clinical development plans and clinical trials for programmes in the Early Pipeline Unit.
Provide translational and clinical leadership in defining and executing innovative early development strategies, ensuring alignment with IEP, CDP, scientific rationale, regulatory requirements, product development plan and commercial goals.
Ensure alignment of scientific and clinical strategies with business objectives through matrix leadership of large cross‑functional teams.
Drive evaluation of therapeutic potential and clinical tractability of targets within the disease area.
Identify transformational opportunities where projects can offer significant benefits to patients.
Ensure quality, on-time, and on-budget delivery of studies and programs within a therapeutic area of EPU.
Design and implement experimental medicine studies.
Oversee risk assessment across programs and implement mitigation strategies.
Manage, mentor and coach early Clinical Development Leads.
Collaborate with cross‑functional teams with program counterparts in Advance Pipeline Unit, Commercial, Research Tech and Development organisations.
Build and maintain networks across internal and external stakeholders, including academic institutions, CROs, and regulators.
Represent GSK effectively in external collaborations and negotiations.
Anticipate challenges and proactively develop strategies to mitigate risks.
Make decisions balancing risk/benefit with clear understanding of project impact.
Lead the writing and review of study‑related documents and regulatory submissions.
Communicate confidently and effectively at all levels, internally and externally.
Champion implementation of innovative business processes and strategies to improve clinical development outcomes.
Basic Qualifications
Academic physician with clinical medical specialty registration, board certification or qualification.
Industry experience in clinical drug development.
Experience with planning clinical development for an asset and/or indication.
Pharmaceutical industry clinical research experience in Aging focused on aging biology; geroscience or age‑related diseases; and potential therapeutic areas.
Direct line management and leadership experience.
Preferred Qualifications
Specialist physician with PhD.
Proven record of creative problem‑solving in clinical trials and projects, such as deriving causal confidence from novel sources or qualifying a novel endpoint.
Experience working collaboratively with multiple stakeholders on complex projects.
Knowledge of translational medicine, clinical research methodology and principles of biostatistics to facilitate innovative and efficient designs of clinical trials and clinical development plans with clear data‑driven decision rules.
Track record of building and maintaining strong relationships with internal and external stakeholders.
Strong personal network across relevant scientific and clinical thought leaders, institutions and consortia in relevant therapy area.
Future‑looking and experimental track record, with demonstrable experience of tech‑enable solutions in biology, translation or clinical development.
Salary and Benefits
For U.S. locations (Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA) annual base salary ranges from $284,625 to $474,375. The position also offers an annual bonus and eligibility to participate in a share‑based long‑term incentive program. Benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.
Equal Employment Opportunity
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
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