UNIV - Postdoctoral Fellow – Pathology and Laboratory Medicine (Neurovascular Re
Medical University of South Carolina, Orleans Estates, SC, United States
Job Description Summary
We are seeking highly motivated individuals for a Postdoctoral Fellow position to study neurovascular function and neuroinflammation in projects that span both basic and translational research. Our recently NIH‑funded research focuses on the role of pericytes in neurovascular dysfunction associated with Alzheimer’s disease and sepsis. We investigate how pericyte‑mediated vascular dysfunction contributes to altered blood‑brain barrier permeability and cerebral blood flow, a significant factor in dementia and Alzheimer’s disease. Our work seeks to deepen the mechanistic understanding of pericyte function while identifying clinically relevant therapeutic strategies. We employ a wide range of complementary approaches, including molecular and cellular biology, advanced imaging technologies, and genetically modified mouse models. Our recently acquired two‑photon microscope enhances our ability to conduct cutting‑edge in‑vivo imaging. The postdoctoral fellow will be supervised by Dr. Hongkuan Fan, Department of Pathology and Laboratory Medicine, who will provide training and mentorship in neurovascular and neuroinflammation research.
Qualifications
Ph.D. and/or M.D. in neuroscience, immunology, vascular biology, or a related discipline.
Strong communication and organizational skills.
Prior experience with small animal surgery and two‑photon imaging highly preferred.
Job Responsibilities
Lead an independent project related to neurovascular function in sepsis or Alzheimer’s disease (35%).
Perform complex experiments and data analysis; manage animal surgeries and breeding colonies (35%).
Operate and maintain lab equipment (optical, mechanical, and electrical devices); assist with related lab projects as needed (15%).
Conduct literature reviews, maintain detailed lab notebooks, and contribute to manuscript preparation (15%).
Preferred Experience & Additional Skills
Ph.D. in biology, neuroscience, immunology, vascular biology, or a related field.
Experience with in‑vivo imaging (two‑photon microscopy) and mouse surgical techniques highly desirable.
Minimum Requirements
Ph.D. or M.D./Ph.D. in a relevant scientific field.
Physical Requirements
Continuous: ability to perform job functions in an upright and seated position; work indoors; maintain tactile and olfactory functions; lift and carry up to 15 lbs. unassisted; maintain 20/40 vision, corrected.
Frequent: ability to walk/mobile; operate in all cold temperature extremes; lift and carry up to 15 lbs. from floor to 72 inches; push/pull objects up to 15 lbs.; perform repetitive motions with hands/wrists/elbows and shoulders.
Infrequent: ability to climb stairs; lift and carry objects to five floors and outlying buildings; perform gross motor functions with frequent fine motor movements; qualifying for respirator use.
Additional: ability to obtain and maintain a valid driver’s license, computer literacy, work rotating shifts and overtime as required; learn and use new processes, tools and equipment as required.
EEO Statement
The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.
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We are seeking highly motivated individuals for a Postdoctoral Fellow position to study neurovascular function and neuroinflammation in projects that span both basic and translational research. Our recently NIH‑funded research focuses on the role of pericytes in neurovascular dysfunction associated with Alzheimer’s disease and sepsis. We investigate how pericyte‑mediated vascular dysfunction contributes to altered blood‑brain barrier permeability and cerebral blood flow, a significant factor in dementia and Alzheimer’s disease. Our work seeks to deepen the mechanistic understanding of pericyte function while identifying clinically relevant therapeutic strategies. We employ a wide range of complementary approaches, including molecular and cellular biology, advanced imaging technologies, and genetically modified mouse models. Our recently acquired two‑photon microscope enhances our ability to conduct cutting‑edge in‑vivo imaging. The postdoctoral fellow will be supervised by Dr. Hongkuan Fan, Department of Pathology and Laboratory Medicine, who will provide training and mentorship in neurovascular and neuroinflammation research.
Qualifications
Ph.D. and/or M.D. in neuroscience, immunology, vascular biology, or a related discipline.
Strong communication and organizational skills.
Prior experience with small animal surgery and two‑photon imaging highly preferred.
Job Responsibilities
Lead an independent project related to neurovascular function in sepsis or Alzheimer’s disease (35%).
Perform complex experiments and data analysis; manage animal surgeries and breeding colonies (35%).
Operate and maintain lab equipment (optical, mechanical, and electrical devices); assist with related lab projects as needed (15%).
Conduct literature reviews, maintain detailed lab notebooks, and contribute to manuscript preparation (15%).
Preferred Experience & Additional Skills
Ph.D. in biology, neuroscience, immunology, vascular biology, or a related field.
Experience with in‑vivo imaging (two‑photon microscopy) and mouse surgical techniques highly desirable.
Minimum Requirements
Ph.D. or M.D./Ph.D. in a relevant scientific field.
Physical Requirements
Continuous: ability to perform job functions in an upright and seated position; work indoors; maintain tactile and olfactory functions; lift and carry up to 15 lbs. unassisted; maintain 20/40 vision, corrected.
Frequent: ability to walk/mobile; operate in all cold temperature extremes; lift and carry up to 15 lbs. from floor to 72 inches; push/pull objects up to 15 lbs.; perform repetitive motions with hands/wrists/elbows and shoulders.
Infrequent: ability to climb stairs; lift and carry objects to five floors and outlying buildings; perform gross motor functions with frequent fine motor movements; qualifying for respirator use.
Additional: ability to obtain and maintain a valid driver’s license, computer literacy, work rotating shifts and overtime as required; learn and use new processes, tools and equipment as required.
EEO Statement
The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.
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