Sr Scientist I Pharmacology
BioSpace, North Chicago, IL, United States
Purpose
Drive the discovery of innovative therapies and treatments for obesity by designing and executing creative experimental strategies grounded in molecular pharmacology, with emphasis on GPCR signaling, trafficking, and efficacy. Lead efforts to develop and optimize advanced in‑vitro biochemical and cell‑based assays to produce high‑quality data with direct translational impact. Propel scientific innovation in GPCR pharmacology and obesity research by fostering robust, cross‑functional collaborations, integrating multidisciplinary expertise, and leveraging technological advancements to accelerate drug discovery.
Responsibilities
Demonstrate scientific initiative and creativity in GPCR pharmacology research and development activities.
Independently develop and validate cell‑based and biochemical assays to characterize GPCRs.
Apply advanced techniques to assess biased agonism, receptor internalization, trafficking, and signaling pathway modulation.
Utilize high‑throughput screening methods to identify novel GPCR modulators.
Implement emerging technologies, such as biosensor assays and CRISPR‑based gene editing, for assay development.
Analyze and interpret complex data to draw conclusions and inform decision‑making.
Collaborate with cross‑functional teams, including chemists, to support obesity research projects and SAR analyses.
Maintain accurate and detailed records of experiments and results and adhere to corporate safety and compliance standards.
Serve as primary author for scientific and regulatory reports and present findings to appropriate stakeholders.
Qualifications
Bachelor’s or Master’s degree (or equivalent education) with the following typical experience requirements: 10 years for Bachelor’s, 8 years for Master’s; PhD with no experience required.
Degree in Pharmacology, Cell Biology, Biochemistry, or related discipline (preferred) with relevant post‑graduate experience.
Familiarity with quantitative assay development, data analysis, and interpretation in drug discovery.
Experience in obesity, metabolic, or related disease area research is strongly preferred.
Demonstrated ability to think independently, troubleshoot, and lead projects.
Experience with laboratory automation and high‑throughput screening is a plus.
Ability to thrive in a fast‑paced, cross‑functional, and dynamic environment; function independently, communicate effectively, and collaborate closely with others.
Compensation & Benefits
Competitive base pay with a disclosed compensation range based on job grade and location.
Comprehensive benefits package including paid time off (vacation, holidays, sick), medical, dental, vision insurance, and a 401(k) plan for eligible employees.
Eligibility to participate in short‑term incentive programs.
Equal Opportunity Employer
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, and serving our community. Equal Opportunity Employer/Veterans/Disabled.
Location Statement
US & Puerto Rico only – to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html.
Accommodation
US & Puerto Rico applicants seeking a reasonable accommodation can learn more at https://www.abbvie.com/join-us/reasonable-accommodations.html.
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Drive the discovery of innovative therapies and treatments for obesity by designing and executing creative experimental strategies grounded in molecular pharmacology, with emphasis on GPCR signaling, trafficking, and efficacy. Lead efforts to develop and optimize advanced in‑vitro biochemical and cell‑based assays to produce high‑quality data with direct translational impact. Propel scientific innovation in GPCR pharmacology and obesity research by fostering robust, cross‑functional collaborations, integrating multidisciplinary expertise, and leveraging technological advancements to accelerate drug discovery.
Responsibilities
Demonstrate scientific initiative and creativity in GPCR pharmacology research and development activities.
Independently develop and validate cell‑based and biochemical assays to characterize GPCRs.
Apply advanced techniques to assess biased agonism, receptor internalization, trafficking, and signaling pathway modulation.
Utilize high‑throughput screening methods to identify novel GPCR modulators.
Implement emerging technologies, such as biosensor assays and CRISPR‑based gene editing, for assay development.
Analyze and interpret complex data to draw conclusions and inform decision‑making.
Collaborate with cross‑functional teams, including chemists, to support obesity research projects and SAR analyses.
Maintain accurate and detailed records of experiments and results and adhere to corporate safety and compliance standards.
Serve as primary author for scientific and regulatory reports and present findings to appropriate stakeholders.
Qualifications
Bachelor’s or Master’s degree (or equivalent education) with the following typical experience requirements: 10 years for Bachelor’s, 8 years for Master’s; PhD with no experience required.
Degree in Pharmacology, Cell Biology, Biochemistry, or related discipline (preferred) with relevant post‑graduate experience.
Familiarity with quantitative assay development, data analysis, and interpretation in drug discovery.
Experience in obesity, metabolic, or related disease area research is strongly preferred.
Demonstrated ability to think independently, troubleshoot, and lead projects.
Experience with laboratory automation and high‑throughput screening is a plus.
Ability to thrive in a fast‑paced, cross‑functional, and dynamic environment; function independently, communicate effectively, and collaborate closely with others.
Compensation & Benefits
Competitive base pay with a disclosed compensation range based on job grade and location.
Comprehensive benefits package including paid time off (vacation, holidays, sick), medical, dental, vision insurance, and a 401(k) plan for eligible employees.
Eligibility to participate in short‑term incentive programs.
Equal Opportunity Employer
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, and serving our community. Equal Opportunity Employer/Veterans/Disabled.
Location Statement
US & Puerto Rico only – to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html.
Accommodation
US & Puerto Rico applicants seeking a reasonable accommodation can learn more at https://www.abbvie.com/join-us/reasonable-accommodations.html.
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