Senior / Principal Scientist - Preclinical PK/PD Modelling and Simulation

Senior / Principal Scientist - Preclinical PK/PD Modelling and Simulation
The Position
Unleash your passion, embrace the science, and make an impact.

As a Senior/ Principal Scientist in Global Preclinical PK/PD Modelling within ‘Global Drug Discovery Sciences’, you will be an integral part of our multidisciplinary research teams and drive model-informed decision making in and beyond the drug discovery stage. You will live our “learn-and-confirm” mentality and strongly interact with our drug metabolism and pharmacokinetic (DMPK), NBE pharmacokinetic, Medicinal Chemistry, Biotherapeutics Discovery, as well as biomarker and pharmacology disciplines within our international project teams.

The mission of our Research Department ‘Global Drug Discovery Sciences’ is to find high-quality first-in-class drug candidates. Our ambition is to make significant contributions to breakthrough therapeutic concepts by providing excellence in drug screening, profiling, optimization, and translation to ensure seamless transition of drug candidates to Development. Join Global Preclinical PK/PD Modelling and Simulation at the company’s largest Research & Development site.

Discover our Biberach site: xplorebiberach.com. This position can be filled either as Senior Scientist or Principal Scientist. This position has a hybrid setup with approximately 3-4 days per week on site.

Tasks & responsibilities

In your new role, you will perform high-quality PK/PD modelling and simulation analyses to support research projects by contributing to informative study designs of preclinical PK and/or PD experiments, by performing high-quality human PK and dose predictions and by contributing to strategies to better understand the PK/PD relations of our candidate drugs.

You will contribute to achieving modelling-related goals for Discovery Research by representing Preclinical PK/PD Modelling in international Research Project Teams.

You will represent and coordinate Research DMPK or NBE PK in international Research Project Teams. This includes establishing and maintaining external collaborations and supporting licensing activities.

As a Principal Scientist, you will lead the coordination of all Drug Discovery Sciences disciplines, which include Research DMPK, NBE PK, CMC, Bioanalytic, and Biomarker functions, in international Research Project Teams.

You will shape and implement PK/PD modelling strategies and approaches for specific Therapeutic Areas / indications, including the definition of modelling-related goals for Discovery Research.

Furthermore, you will coach and support the development of (junior) research scientists.

Requirements

PhD in a field related to (preclinical) PK/PD modelling with several years of relevant experience in PK/PD modelling and simulation; Industry experience is considered beneficial

A solid knowledge in biology, DMPK and/or pharmacology

Proven skills in PK, PK/PD, PBPK, and / or longitudinal disease modelling

Proficiency in (statistical) programming languages and pharmacometric tools e.g., R, MATLAB, Phoenix WinNonLin, NONMEM

Authentic, enthusiastic, cooperative, and creative personality with excellent communication skills in English

Additional requirements as Principal Scientist

PhD with long-term experience in a field related to (preclinical) PK/PD modelling, pharmacometrics, applied mathematics, systems biology, bioinformatics or similar; Industry experience is considered beneficial

In-depth understanding of (preclinical) PK/PD modelling and simulation, as well as pharmacology and DMPK- and/or NBE PK- related topics

Experience in working in and leading matrix-style project teams

Applications from people with severe disabilities are warmly welcomed. In cases of equal qualifications, such applicants will be given preferential consideration in the selection process.

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