Lead Full-Stack Developer: C#/.NET, Cloud & CI/CD (Hybrid)

Theradex Systems, Inc.

Theradex is an Equal Opportunity Employer.

US-NJ-Princeton | US
ID

2026-1426
Category

Information Technology
Type

Full Time

Celebrating 40+ years!
Theradex Oncology is a full-service CRO specializing in oncology. The company manages global oncology trials and programs. The company was founded in 1982 working with the National Cancer Institute, which led to its expansion to working with industry sponsors developing cancer therapeutics. As a service-based company we support both domestic and international sponsors in the conduct of both early and late phase trials.

Location: Princeton, NJ (Hybrid – Onsite 3 days/week preferred) - Will consider regionally remote candidates
As part of Theradex Oncology, you will have the opportunity to work with one of the largest professional teams focused solely on the development of cancer therapies. Cancer research continues to evolve as new therapies and therapeutic approaches are discovered, as part of the team you will work to support our sponsors in the development of these therapies. Theradex Oncology is an environment for highly motivated individuals who want to make a difference.
About the Role

We are seeking a Lead Full Stack Developer responsible for designing, building and operating end-to-end web applications and data driven solutions that support clinical trial operations. This is a hands-on technical leadership role, combining senior individual contributor responsibilities with mentoring and guiding other developers on modern practices.

This role requires recent hands-on experience owning technical solutions and driving projects forward while maintaining Full Stack Development responsibilities.
Key Responsibilities
Oversees application development team's technical delivery across all projects while remaining a hands-on Full Stack Developer.
Design and implement scalable, secure frontend and backend components, including APIs, services and UI workflows, following clean architecture and solid principles.
Embed application security best practices into the software development lifecycle, including securing code, code scanning, dependency management, and remediation of vulnerability identified through AppSec tools.
Collaborate with product owners, technical analysts, project managers, platform engineering and analytics teams to translate complex business needs into practical technical solutions.
Own technical solutions end to end: architecture, implementation, testing, deployment, and support.
Establish and champion coding standards, automated testing, and CI/CD pipelines to improve quality, reliability and release frequency. Mentor and guide other developers; enforce engineering best practices, code quality, and architectural integrity.
Collaborate with Solutions Architect, DevOps, and Data teams to translate business needs into scalable technical designs.
Ensure all development follows SDLC, validation, GxP, and 21 CFR Part 11 requirements.
Design secure integrations with external clinical and operational systems.
Troubleshoot complex system issues and lead root cause analysis.
Drive continuous improvement in cloud performance, cost optimization, security posture, and CI/CD automation.
Understand and continue to stay current with the AWS Cloud development environment and tools that the systems utilize.
Manage time effectively and accurately estimate effort for tasks and meets agreed-upon deadlines.
Adapt to frequently changing requirements, priorities, and schedules.
Troubleshoot and resolve technical issues in a timely manner, performs root cause analyses, and drives permanent fixes and technical debt reduction.
Contribute to architecture discussions and technology choices, balancing innovation with maintainability and regulatory constraints.
Promote a culture of documentation, knowledge sharing and continuous learning within the application development team. Provide technical mentorship and oversight through design reviews, pairing programming and structured feedback.

Minimum 8 years of experience as a full stack developer
Minimum 3 years of experience leading a development team focused on building On-prem and Cloud applications

Core stack C#/ASP.NET, .NET, Angular, SQL, NO SQL, and AWS
Proficient in

Angular

and experience in a recent project
Strong experience redeveloping on-prem web applications to be optimized for the AWS Cloud
Experience leading a Cloud software development project

end to end: architecture, implementation, testing, deployment, and support
Experience building AWS based web sites, applications and integrations
AWS services

such as

CloudWatch, SES, S3, ECR, ECS, Lambda

functions
UI/UX

experience using

Blazor or Angular
Relational and non-relational databases
All aspects of

GitHub, including GitHub Actions
Experience with

Docker containers
Strong experience with the management of code through a CI/CD pipeline
Preferred Experience
Experience configuring AWS environment using Terraform, Fargate, etc.
Experience in a CRO/pharmaceutical environment with definitive knowledge of regulated clinical data applications
Knowledge of GxP and 21 CFR Part 11 compliance
Experience with migrating an entire on-prem data center to the AWS Cloud
What We Offer
At Theradex we offer a supportive culture that puts people first. Our employees are eligible to participate in our comprehensive benefits package which includes medical, dental and vision coverage; life insurance, disability insurance (STD/LTD), company matched 401(k), very competitive tuition reimbursement, generous vacation/sick plans, flexible work schedules, employee discounts and other company provided benefits. The annual base salary for this position ranges from $140,000 - $175,000. The actual salary offer will be based on a number of factors, including but not limited to the candidate’s qualifications, experience, skills, and competencies for the role.
This position is not eligible for relocation or company provided sponsorship.

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