Market Transformation Director - Direct to Patient

Job Overview

Vertex is seeking a strategic and execution-focused Director, Market Transformation to lead the design, evaluation and implementation of direct-to-patient (DTP) capabilities across the patient journey. This leader will help shape how patients move from awareness and activation through care, access, therapy start and adherence. The Director will assess where DTP models can create meaningful value, define the right strategy by asset and therapy area, and build scalable capabilities that reduce patient friction and improve measurable conversion. This role requires strong cross‑functional leadership across marketing, patient services, market access, digital, medical, legal, compliance, operations and analytics.
Key Duties and Responsibilities

Develop Vertex’s direct-to-patient strategy across relevant brands, assets and therapeutic areas to improve diagnosis and treatment access for patients
Monitor market trends, competitor activity and emerging digital health models to inform Vertex strategy
Identify and address patient drop‑off points across diagnosis, provider referral, reimbursement, prescription routing and therapy initiation
Evaluate DTP opportunities based on patient drop‑off points and therapy‑area dynamics
Design and optimize end‑to‑end patient pathways spanning awareness, activation, care, conversion, therapy start, and adherence
Build clear business cases for DTP investments, including patient acquisition costs, economics, lifetime value modeling, infrastructure costs, conversion assumptions, and ROI measurement
Define and implement DTP models such as journey orchestration, access navigation, direct commerce and go‑to‑market reconfiguration
Partner cross‑functionally to connect fragmented patient touchpoints into a seamless experience
Establish shared goals, KPIs and governance across brand, access, digital, trade and patient support teams
Lead the development of modular enterprise capabilities that can scale across the portfolio rather than being built brand by brand
Oversee external partnerships and vendor strategy for telehealth, pharmacy, fulfillment, diagnostics and digital engagement solutions
Drive innovation in patient engagement, including symptom‑based education, screening, targeting, retargeting and closed‑loop optimization
Ensure all DTP initiatives align with legal, regulatory, privacy, data governance and patient experience standards
Serve as a thought partner to senior leadership on the future of patient engagement and access transformation
Required Qualifications

Bachelor’s degree in business, life sciences, public health, healthcare administration or related field; advanced degree such as MBA, MPH, MS or other relevant graduate degree preferred
8+ years of experience in biopharma, healthcare, digital health or patient services
5+ years of leadership experience in one or more of the following: patient access, commercialization, patient support services, digital health, market access, and omnichannel patient engagement
Demonstrated experience designing or scaling patient‑centric programs across multiple stages of the patient journey
Strong understanding of pharmaceutical commercialization, specialty access models and reimbursement dynamics
Experience building business cases, operating models and strategic roadmaps for new capabilities or channels
Proven success leading complex cross‑functional initiatives with multiple internal and external stakeholders
Strong analytical and problem‑solving skills, with the ability to translate data into strategic recommendations
Excellent executive communication and presentation skills
Experience working in highly regulated environments and navigating legal/compliance requirements
Knowledge and Skills

Patient journey mapping and funnel analysis
DTP and omnichannel engagement strategy
Access and reimbursement strategy
Benefits verification and prior authorisation workflows
Telehealth and virtual care partnership models
Prescription routing and e‑prescribing integration
Patient support and adherence program design
Digital acquisition channels, including paid media, SEO and content strategy
Screening, assessment and diagnostic coordination workflows
CRM and patient engagement platforms
Data analytics, dashboarding and KPI development
AI‑enabled targeting, triage or documentation tools
Understanding of EHR, HIE or medical record‑enabled workflows
Vendor management and partnership governance
Knowledge of legal, privacy and data orchestration considerations across patient‑facing programmes
Preferred Skills

Experience launching or managing DTP, direct commerce or digitally enabled patient access models
Knowledge of specialty therapies, complex treatment pathways or high‑friction access environments
Experience with cash‑pay, affordability or alternative payment pathway models
Familiarity with non‑dispensing pharmacy, hub services and specialty distribution models
Experience integrating digital, medical, market access and commercial strategies into a unified patient pathway
Strong understanding of patient experience design and service operations
Comfort working in ambiguous, fast‑evolving spaces and building new capabilities from the ground up
Education and Experience

Bachelor’s degree required; typically requires 10 years of work experience and 3 years of supervisory/management experience, or the equivalent combination of education and experience.
Pay Range

$196,000 - $294,000
Flex Designation

Hybrid‑Eligible or On‑Site Eligible. In this Hybrid‑Eligible role, you can choose to be designated as: 1) Hybrid: work remotely up to two days per week; or 2) On‑Site: work five days per week on‑site with ad‑hoc flexibility.
EEO Statement

Vertex is committed to equal employment opportunity and non‑discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E‑Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com.

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