The Associate Director of Translational/Preclinical Modeling develops and implements quantitative and mechanistic PK/PD models to aid in the understanding of target biology, therapeutic modality selection/optimization, and contributes to early clinical trial dose selection and/or design and advances the strategic direction of modeling and simulation sciences.
A Typical Day May Include
- Independently develop and implement quantitative and mechanistic mathematical PK/PD models that inform preclinical-to-early clinical translation, including human efficacious dose predictions and first-in-human dose selection.
- Actively contribute to the advancement and strategic direction of modeling and simulation sciences.
- Provide expert support to pre‑clinical PK/PD project representatives and R&D project teams to design, execute and interpret in vitro and in vivo quantitative pharmacology studies, including working with the Research PK group to optimize use of mouse PK data to inform translation to nonhuman primate and human PK.
- Effectively integrate and summarize modeling and simulation analyses into usable information for multidisciplinary project teams.
- Remain apprised of emerging science and literature, and effectively collaborate with subject matter experts in Clinical Pharmacology, Quantitative Pharmacology and R&D to advance modeling and simulation sciences.
- Present work at internal and external scientific meetings and publish work in scientific journals.
This Role Might Be For You If
- Experience using one or more modeling and simulation platforms (e.g., Phoenix NLME, NONMEN, Monolix, ADAPT, MATLAB, SimBiology).
- Strong theoretical and practical foundation in pharmacokinetics, including non‑compartmental, compartmental, PK/PD and PBPK.
- Effectively work in a fast‑paced, highly‑matrixed team‑based environment and leverage scientific reasoning to influence key stakeholders.
- Ability to learn new areas of biological sciences to develop quantitative and mechanistic PK/PD models for emerging therapeutic modalities.
- Familiarity with biotherapeutic modalities, including monoclonal and bispecific antibodies, gene therapy, CAR‑T, siRNAs and other targeting agents.
To Be Considered For This Position, You Must Have
Ph.D. or M.S. in pharmacokinetics, pharmaceutical sciences, engineering, applied mathematics or related disciplines with a track record of applying quantitative and mechanism‑based PK/PD modeling and simulation approaches to advance the discovery and development of therapeutics. Greater than 6 years of pharmaceutical industry or related experience in developing and applying mechanism‑based PK/PD models to guide R&D teams from early discovery to IND‑stage clinical development.
Salary Range (annually)
$176,100.00 – $287,300.00
Benefits include comprehensive health and wellness programs, medical, dental, vision, life and disability insurance, fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off and paid leaves. Salaries and benefits vary by location and may differ for non‑U.S. candidates.
Regeneron is an equal‑opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, national origin, disability, age or any other protected characteristic. The Company will provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.
Background checks will form part of the recruitment process. They will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted to verify identity, right to work, educational qualifications and other relevant information.
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