Responsibilities
- Build and validate predictive models across key ADMET and PK/PD endpoints (clearance, permeability, solubility, metabolic stability, DDI risk, transporter liabilities, exposure–toxicity relationships, and PK/PD) grounded in mechanistic understanding and designed for partner use.
- Develop translational modeling approaches (PBPK, IVIVE, and PK/PD simulation) to bridge preclinical and clinical settings and generate actionable predictions for biotech partners across diverse programs and modalities.
- Develop mechanistic and data-driven distribution models for tissue distribution, volume of distribution, plasma protein binding, and blood-brain barrier penetration; calibrate across relevant species for translatable human predictions.
- Translate complex ADMET and PK/PD science into practical, interpretable model outputs and workflows; create documentation, decision frameworks, and companion guidance for partner usability.
- Define data requirements and validation approaches to ensure models are scientifically sound, reproducible, and fit for purpose; identify training data gaps and collaborate to address them.
- Leverage AI and agentic tools to automate data pipelines, improve model interpretability, and streamline partner output delivery across a federated network.
- Provide coaching/mentorship to junior scientists and help grow TuneLab’s ADMET and PK/PD modeling capabilities.
Qualifications
- PhD in Pharmaceutical Sciences, Pharmacokinetics, Pharmacometrics, Clinical Pharmacology, Drug Metabolism, Toxicology, or related STEM.
- 7+ years relevant experience in ADME/PKPD, Pharmacometrics, Translational Medicine, or closely related field.
Additional Skills/Preferences
- Hands‑on experience with modeling platforms (SimCYP, GastroPlus, PK-Sim, NONMEM, Monolix, R, Matlab, etc.).
- Knowledge of medicinal chemistry and/or toxicology principles.
- Experience with small molecule discovery (Beyond‑Rule‑of‑Five, pan‑modality chemotypes).
- Strong communication skills to explain complex quantitative science.
- Track record of scientific contributions in pharmacokinetics, pharmacodynamics, ADMET, or pharmaceutical sciences.
Benefits (as stated)
- Anticipated wage: $177,000 - $308,000.
- Company bonus for full‑time equivalent employees (depending on company/individual performance).
- 401(k), pension, vacation, medical/dental/vision/prescription benefits, flexible benefits (healthcare/dependent day care FSAs), life insurance/death benefits, time off/leave benefits, and well‑being benefits (EAP, fitness benefits, clubs/activities).
Application instructions – if you require accommodation to submit a resume: complete the workplace accommodation request form at
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