Senior Scientist, Translational PK/PD

Job Description

The department of Pharmacokinetics, Dynamics, Metabolism & Bioanalytics (PDMB) is seeking a curious and collaborative Senior Scientist for our growing Translational PK/PD organization. The Translational PK/PD Senior Scientist is a skilled mathematical modeler and scientist who designs and executes analyses, with supervision, guiding drug discovery strategy with a focus on biologics, protein therapeutics, and peptides.
The Translational PK/PD Senior Scientist Will

Serve as PK/PD modeler in cross-functional teams, to make model-informed decisions about drug discovery, modality selection, and dose prediction across therapeutic areas;
Integrate in vitro and in vivo data to build PKPD, PBPK, quantitative systems pharmacology (QSP), or other mechanistic modeling platforms of drug disposition and pharmacology, to support forward/reverse translation for both established and novel therapeutic targets;
Collaborate across our PDMB and broader Discovery / Translational organization to design experimental studies and modeling plans, to identify and optimize drug candidates;
Collaborate in the design of automated workflows for implementing modeling platforms, to inform human PK/PD and dose projections;
With guidance from experienced modelers, continue to build expertise and leadership skills in translational modeling and drug discovery.
In addition to the responsibilities described above, the Senior Scientist will demonstrate strong leadership and communication skills, drawing upon their training and experience to enable model-informed drug discovery.
NOTE: This role is available in South San Francisco, CA, West Point, PA or Boston, MA based on candidate preference.

Qualifications

Education:

Master's (with 3+ years), PharmD (with 1 year) or Ph.D. in pharmacokinetics/pharmacodynamics, mathematics, applied mathematics, systems biology, computational biology, chemical/biomedical engineering, statistics/biostatistics or related discipline and experience with increasing responsibility and independence in drug discovery / development, within industry, academia, regulatory or non-profit settings
Required Experience And Skills

Experience performing hands-on translational PKPD modeling using standard modeling software (e.g., Matlab, OSP Suite, Monolix, R)
Strong skills in experimental design, mathematical problem solving, critical data analysis/interpretation, and/or statistics
Preferred Experience And Skills

Experience using mathematical modeling to inform decisions related to discovery / development of biologics, protein therapeutics, and/or peptides
Demonstrated ability to work in interdisciplinary teams and in collaborative problem solving
Expertise in developing novel PKPD, PBPK, QSP, or related mechanistic modeling approaches
Required Skills

Biostatistics, Data Analysis, Data Modeling, Data Science, Drug Discovery Process, Interdisciplinary Collaboration, MATLAB, Pharmacodynamics, Pharmacokinetics, PKPD Modeling, Statistical Analysis, Translational Pharmacokinetics and Pharmacodynamics (PKPD)
Preferred Skills

US And Puerto Rico Residents Only

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
Requirements

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:
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We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.
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Salary

The salary range for this role is
$129,000.00 - $203,100.00
This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organisational needs.
The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.
Location-Specific Statements

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance.
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance.
Employee Status

Regular
Relocation

Domestic/International
VISA Sponsorship

Yes
Travel Requirements

10%
Flexible Work Arrangements

Hybrid
Shift

1st - Day
Valid Driving License

No
Hazardous Material(s)

N/A
Job Posting End Date

09/30/2026
A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Requisition ID: R411925

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