Director, ADC Chemistry
Klein Hersh International, San Francisco, CA, United States
Our client is a publicly traded oncology biotech with multiple approved products and a growing pipeline.
The Director, ADC Chemistry will play a key role in leading the efforts for advancing the discovery and development of antibody drug conjugates (ADCs) for our client by leveraging his/her knowledge of medicinal chemistry. They will support efforts in discovery research and early process development activities of ongoing and new ADC projects.
Key Responsibilities:
Lead, build and execute antibody on ADC pipeline programs. Provides ADC chemistry expertise in state-of-the-art ADC technologies including linkers, payloads, novel conjugation methods, analytical assessments and testing and bring novel ideas to POC. Technical expert from Biotherapeutics group on ADC-related internal projects. Interacts and collaborates with internal departments and external colleagues to discuss and resolve project needs and issues in research and early development of ADCs. Provides support in evaluation of ADC research platforms and preclinical licensing candidates as needed. Provides critical scientific/technical data analysis, interpretation of experiments and report writing. Design, implement and oversee the execution of in vitro bio-functional assays such as efficacy/bystander/metabolite assessments/bioanalysis/mechanism of action studies/etc. for bioconjugate candidate screening and selection as needed from discovery to lead selection. Effectively communicates scientific concepts, study findings and interpretations to multi-disciplinary teams. Interacts and collaborates with internal departments to deliver quality and timely findings in support of drug candidate advancement. Lead scientific efforts in cancer target identification/validation. Manage, supervise, plan and prioritize workflow for laboratory-based scientific staff. Follows company intellectual property and compliance policies and practices. Complies with company health and safety policies and general laboratory practices. Key Requirements:
Bachelor’s degree in chemistry, biochemistry, biology or a related discipline and a minimum of thirteen years of related experience; or, Master’s degree in chemistry, biochemistry, biology or a related discipline and a minimum of eleven years of related experience; or, PhD degree in chemistry, biochemistry, biology or a related discipline and a minimum of eight years of related experience; or, Equivalent combination of education and experience. Knowledge of state-of-the-art in different aspects of ADC research including conjugation technologies, linkers and payloads. Extensive knowledge of ADC platforms, applications and development. Comprehensive understanding of current approaches and emerging technologies in ADCs. Strong background in chemistry and/or biochemistry. Knowledge of intellectual property matters, and issues related to ADCs. The knowledge to apply advanced scientific and technical principles, theories and concepts, and contribute to the development of new principles and concepts. Ability to work independently, excellent time management and organization skills to manage multiple projects simultaneously. Excellent written, oral and interpersonal communication skills. Location: Bay Area (onsite)
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Lead, build and execute antibody on ADC pipeline programs. Provides ADC chemistry expertise in state-of-the-art ADC technologies including linkers, payloads, novel conjugation methods, analytical assessments and testing and bring novel ideas to POC. Technical expert from Biotherapeutics group on ADC-related internal projects. Interacts and collaborates with internal departments and external colleagues to discuss and resolve project needs and issues in research and early development of ADCs. Provides support in evaluation of ADC research platforms and preclinical licensing candidates as needed. Provides critical scientific/technical data analysis, interpretation of experiments and report writing. Design, implement and oversee the execution of in vitro bio-functional assays such as efficacy/bystander/metabolite assessments/bioanalysis/mechanism of action studies/etc. for bioconjugate candidate screening and selection as needed from discovery to lead selection. Effectively communicates scientific concepts, study findings and interpretations to multi-disciplinary teams. Interacts and collaborates with internal departments to deliver quality and timely findings in support of drug candidate advancement. Lead scientific efforts in cancer target identification/validation. Manage, supervise, plan and prioritize workflow for laboratory-based scientific staff. Follows company intellectual property and compliance policies and practices. Complies with company health and safety policies and general laboratory practices. Key Requirements:
Bachelor’s degree in chemistry, biochemistry, biology or a related discipline and a minimum of thirteen years of related experience; or, Master’s degree in chemistry, biochemistry, biology or a related discipline and a minimum of eleven years of related experience; or, PhD degree in chemistry, biochemistry, biology or a related discipline and a minimum of eight years of related experience; or, Equivalent combination of education and experience. Knowledge of state-of-the-art in different aspects of ADC research including conjugation technologies, linkers and payloads. Extensive knowledge of ADC platforms, applications and development. Comprehensive understanding of current approaches and emerging technologies in ADCs. Strong background in chemistry and/or biochemistry. Knowledge of intellectual property matters, and issues related to ADCs. The knowledge to apply advanced scientific and technical principles, theories and concepts, and contribute to the development of new principles and concepts. Ability to work independently, excellent time management and organization skills to manage multiple projects simultaneously. Excellent written, oral and interpersonal communication skills. Location: Bay Area (onsite)
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