Sr. Manager/Associate Director Chemistry

Corvus Pharmaceuticals, South San Francisco, CA, United States

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$160,000.00/yr - $195,000.00/yr

Independently design synthetic strategies and use those strategies to synthesize and characterize precursor compounds, starting materials, intermediates, reference compounds, and new chemical entities
Design small-molecule drug candidates based on in vitro and in vivo biological activity, ADME/PK, physicochemical and IP-relevant data.
Purify and characterize molecules with standard analytical techniques (e.g. HPLC, LCMS, NMR)
Use computation and structural data and information to design molecules
Perform research and/or development in collaboration with others in chemistry and biology; make detailed observations and analyzes data.
Prepare batch records, technical reports, summaries, protocols and quantitative analyses
Write and review manuscripts for publication
Provide support in corporate research and development of patent applications
Develop strategies to ensure effective achievement of scientific objectives
Uses skills to contribute to development of company objectives and principles and to achieve goals in creative and effective ways
Exercises independent judgment in selecting methods, techniques and evaluation criteria for obtaining results

PhD in Chemistry plus 5+ years of related experience in pharmaceutical or biotechnology industry or equivalent.
Demonstrated expertise in synthetic organic chemistry
Must possess expert knowledge of scientific principles and concepts.
A solid understanding of modern analytical techniques (NMR, HPLC, MS)
Excellent verbal and written communication skills and the ability to collaborate effectively within a multidisciplinary team

Experience in designing and synthesizing PROTACs or molecular glues is strongly preferred
Molecular modeling and computational methods
Able to manage outside vendor collaborations
Flexibility and willingness to solve problems that fall outside of immediate area of expertise
Work independently in an interdisciplinary, fast-paced, often changing environment.
Committed to the values of integrity, accountability, transparency, and drive.

Local candidates only.

Salary Range: $160,000 to $195,000

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