Senior Scientist, Computational Sciences - Computational Antibody Discovery and
Bristol Myers Squibb, Cambridge, MA, United States
Senior Scientist, Computational Sciences – Computational Antibody Discovery and Design
Location: Cambridge Crossing – MA
#LI-Hybrid
Responsibilities
Own end-to-end computational workflows supporting antibody hit discovery and lead prioritization in pre-clinical programs.
Implement and deploy high-throughput and scalable bioinformatics pipelines to analyze antibody repertoire sequencing and selection NGS data (such as in vitro display or in vivo immunization) with the goal to expedite biologics discovery and design.
Develop predictive models to analyze and characterize antibody repertoire sequencing data to deliver insights on antibody properties, assess fitness to target candidate profile, and ultimately improve lead candidate identification.
Serve as computational science partner in antibody discovery programs, design and execute computational experiments to answer program-specific questions.
Partner with cross-functional project teams to develop bioinformatics & machine learning solutions for novel biotherapeutics.
Communicate scientific findings to collaborators and other stakeholders, propose follow-up actions with measurable scientific outcomes.
Qualifications
Required
PhD in bioinformatics, computer science, engineering, statistics, or similar with 4+ years of relevant industry experience.
In-depth experience analyzing NGS data and building scalable bioinformatics pipelines.
In-depth understanding of antibody sequence and structure.
Strong experience with commonly used bioinformatics methods and toolkits for tasks such as sequence alignment, clustering, annotation, and exploratory analysis.
Strong experience with scientific programming languages (Python, R) and data science libraries.
Ability to independently conduct scientific research, develop hypotheses, and deliver functional and sustainable solutions without technical debt.
Excellent problem-solving skills and teamwork.
Strong communication, documentation, and presentation skills.
Preferred
In-depth experience analyzing NGS data, specifically B-cell receptor repertoires from mice immunization campaigns and synthetic repertoires from in vitro display technologies.
Proven experience building large-scale complex workflows using established workflow orchestrators such as CWL, WDL, Nextflow for high-throughput data analysis.
Experience with state-of-the-art AI/ML methods applied to biological sequence data such as protein language models, structure prediction models, developability and biophysical property prediction models.
Hands‑on experience with public protein and immune repertoire resources such as PDB, OAS, and SAbDab.
Proven track record of effective collaboration in multi-disciplinary team projects.
Compensation Overview
Cambridge Crossing: $148,210 - $179,601
The starting compensation range(s) for this role are listed above for a full‑time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job‑related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.
Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.
Benefits
Health Coverage: Medical, pharmacy, dental and vision care.
Wellbeing Support: Programs such as BMS Well‑Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
Financial Well‑being and Protection: 401(k) plan, short‑ and long‑term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment.
Work‑life benefits include:
Paid Time Off
US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non‑Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
All global employees full and part‑time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.
On‑site Protocol
BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site‑essential, site‑by‑design, field‑based and remote‑by‑design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site‑essential roles require 100% of shifts onsite at your assigned facility. Site‑by‑design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote‑by‑design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
Supporting People with Disabilities
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit https://careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
Candidate Rights
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
Data Protection
We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection.
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.
#J-18808-Ljbffr
Location: Cambridge Crossing – MA
#LI-Hybrid
Responsibilities
Own end-to-end computational workflows supporting antibody hit discovery and lead prioritization in pre-clinical programs.
Implement and deploy high-throughput and scalable bioinformatics pipelines to analyze antibody repertoire sequencing and selection NGS data (such as in vitro display or in vivo immunization) with the goal to expedite biologics discovery and design.
Develop predictive models to analyze and characterize antibody repertoire sequencing data to deliver insights on antibody properties, assess fitness to target candidate profile, and ultimately improve lead candidate identification.
Serve as computational science partner in antibody discovery programs, design and execute computational experiments to answer program-specific questions.
Partner with cross-functional project teams to develop bioinformatics & machine learning solutions for novel biotherapeutics.
Communicate scientific findings to collaborators and other stakeholders, propose follow-up actions with measurable scientific outcomes.
Qualifications
Required
PhD in bioinformatics, computer science, engineering, statistics, or similar with 4+ years of relevant industry experience.
In-depth experience analyzing NGS data and building scalable bioinformatics pipelines.
In-depth understanding of antibody sequence and structure.
Strong experience with commonly used bioinformatics methods and toolkits for tasks such as sequence alignment, clustering, annotation, and exploratory analysis.
Strong experience with scientific programming languages (Python, R) and data science libraries.
Ability to independently conduct scientific research, develop hypotheses, and deliver functional and sustainable solutions without technical debt.
Excellent problem-solving skills and teamwork.
Strong communication, documentation, and presentation skills.
Preferred
In-depth experience analyzing NGS data, specifically B-cell receptor repertoires from mice immunization campaigns and synthetic repertoires from in vitro display technologies.
Proven experience building large-scale complex workflows using established workflow orchestrators such as CWL, WDL, Nextflow for high-throughput data analysis.
Experience with state-of-the-art AI/ML methods applied to biological sequence data such as protein language models, structure prediction models, developability and biophysical property prediction models.
Hands‑on experience with public protein and immune repertoire resources such as PDB, OAS, and SAbDab.
Proven track record of effective collaboration in multi-disciplinary team projects.
Compensation Overview
Cambridge Crossing: $148,210 - $179,601
The starting compensation range(s) for this role are listed above for a full‑time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job‑related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.
Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.
Benefits
Health Coverage: Medical, pharmacy, dental and vision care.
Wellbeing Support: Programs such as BMS Well‑Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
Financial Well‑being and Protection: 401(k) plan, short‑ and long‑term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment.
Work‑life benefits include:
Paid Time Off
US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non‑Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
All global employees full and part‑time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.
On‑site Protocol
BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site‑essential, site‑by‑design, field‑based and remote‑by‑design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site‑essential roles require 100% of shifts onsite at your assigned facility. Site‑by‑design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote‑by‑design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
Supporting People with Disabilities
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit https://careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
Candidate Rights
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
Data Protection
We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection.
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.
#J-18808-Ljbffr