Bioinformatics Research Scientist (TIRTL Collaborative Center)
Thecentermemphis, Memphis, TN, United States
Position Overview
The Tracking the Immune Repertoire of Tumor Lymphocytes (TIRTL) Bluesky program in the Host-Microbe Interactions Department at St. Jude supports multiple institutional research and clinical programs focused on immune repertoire profiling. Building on the foundational TIRTL‑seq method, the program provides cohort‑scale T cell and B cell receptor (TCR and BCR) sequencing to enable research in cancer immunology, infectious disease, and antibody discovery across the institution.
We are seeking a Bioinformatics Research Scientist to develop, maintain, and scale robust computational pipelines that support high‑throughput immune repertoire sequencing and antibody discovery across cancer and infectious disease programs. The scientist will work closely with experimental scientists, clinicians, and data science teams to deliver reproducible, production‑ready analyses as part of a centralized service.
Job Responsibilities
Independently perform basic and advanced statistical analysis, algorithm implementation, and programming across a variety of biotech platforms and oversee quality checks.
Design and prepare training materials on bioinformatics software, databases, computing, data mining, and analysis.
Act as a liaison between end‑users, software developers, system designers, and various departments.
Establish protocols or best practices for common research tasks, evaluate products and solutions, provide recommendations, and integrate solutions.
Lead the development, implementation, installation, and maintenance of databases; coordinate data collection and usage and any related hardware and software.
Develop programs to assist in the analysis of data within the databases.
Plan, coordinate, and organize projects across departments and delegate tasks based on priority, expertise, and capacity.
Perform other duties as assigned to meet departmental and institutional goals.
Maintain regular and predictable attendance.
Develop and maintain bioinformatics pipelines for TCR and BCR repertoire sequencing.
Perform and oversee data QC, statistical analysis, and interpretation of repertoire datasets.
Integrate immune repertoire data with clinical metadata and other multi-omics datasets.
Document and maintain workflows and databases for reproducibility, scalability, and long‑term reuse.
Support infectious disease and host–microbe interaction studies, emphasizing B cell responses and antibody discovery.
Support immuno‑oncology projects, including analysis of tumor‑infiltrating lymphocytes and integration with tumor genomic and clinical data.
Collaborate with investigators and serve as a technical liaison between wet‑lab, clinical, and computational teams.
Contribute to continuous improvement and expansion of TIRTL analytical capabilities.
Preferred Skills
Experience with
immune repertoire analysis
(BCR and/or TCR).
Familiarity with tools and methods for BCR clonotyping, somatic hypermutation analysis, lineage reconstruction, or antigen‑driven selection.
Background in
cancer immunology, infectious disease, or antibody discovery .
Minimum Education and/or Training
Bachelor’s degree in bioinformatics, cheminformatics, statistics, computer science, or a related field with a background in biological sciences or chemistry.
Master’s degree or PhD preferred.
Minimum Experience
Minimum: Bachelor’s degree with 6+ years of post‑degree work in bioinformatics, cheminformatics, statistics, computer science, or related fields.
Experience Exception: Master’s degree with 4+ years of relevant post‑degree experience (or)
PhD with no experience.
Experience in at least one programming or scripting language and at least one statistical package; R preferred.
Significant experience in at least one programming or scripting language and at least one statistical package; Python or R preferred.
Strong experience with high‑throughput sequencing data analysis.
Experience with Linux, HPC environments, version control, and workflow systems.
Compensation
St. Jude provides a reasonable estimate of the compensation range for this role: $86,320 - $154,960 per year for the Bioinformatics Research Scientist (TIRTL Collaborative Center). Specific salary offers consider skill set, experience, training, and other business factors.
St. Jude is an Equal Opportunity Employer.
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The Tracking the Immune Repertoire of Tumor Lymphocytes (TIRTL) Bluesky program in the Host-Microbe Interactions Department at St. Jude supports multiple institutional research and clinical programs focused on immune repertoire profiling. Building on the foundational TIRTL‑seq method, the program provides cohort‑scale T cell and B cell receptor (TCR and BCR) sequencing to enable research in cancer immunology, infectious disease, and antibody discovery across the institution.
We are seeking a Bioinformatics Research Scientist to develop, maintain, and scale robust computational pipelines that support high‑throughput immune repertoire sequencing and antibody discovery across cancer and infectious disease programs. The scientist will work closely with experimental scientists, clinicians, and data science teams to deliver reproducible, production‑ready analyses as part of a centralized service.
Job Responsibilities
Independently perform basic and advanced statistical analysis, algorithm implementation, and programming across a variety of biotech platforms and oversee quality checks.
Design and prepare training materials on bioinformatics software, databases, computing, data mining, and analysis.
Act as a liaison between end‑users, software developers, system designers, and various departments.
Establish protocols or best practices for common research tasks, evaluate products and solutions, provide recommendations, and integrate solutions.
Lead the development, implementation, installation, and maintenance of databases; coordinate data collection and usage and any related hardware and software.
Develop programs to assist in the analysis of data within the databases.
Plan, coordinate, and organize projects across departments and delegate tasks based on priority, expertise, and capacity.
Perform other duties as assigned to meet departmental and institutional goals.
Maintain regular and predictable attendance.
Develop and maintain bioinformatics pipelines for TCR and BCR repertoire sequencing.
Perform and oversee data QC, statistical analysis, and interpretation of repertoire datasets.
Integrate immune repertoire data with clinical metadata and other multi-omics datasets.
Document and maintain workflows and databases for reproducibility, scalability, and long‑term reuse.
Support infectious disease and host–microbe interaction studies, emphasizing B cell responses and antibody discovery.
Support immuno‑oncology projects, including analysis of tumor‑infiltrating lymphocytes and integration with tumor genomic and clinical data.
Collaborate with investigators and serve as a technical liaison between wet‑lab, clinical, and computational teams.
Contribute to continuous improvement and expansion of TIRTL analytical capabilities.
Preferred Skills
Experience with
immune repertoire analysis
(BCR and/or TCR).
Familiarity with tools and methods for BCR clonotyping, somatic hypermutation analysis, lineage reconstruction, or antigen‑driven selection.
Background in
cancer immunology, infectious disease, or antibody discovery .
Minimum Education and/or Training
Bachelor’s degree in bioinformatics, cheminformatics, statistics, computer science, or a related field with a background in biological sciences or chemistry.
Master’s degree or PhD preferred.
Minimum Experience
Minimum: Bachelor’s degree with 6+ years of post‑degree work in bioinformatics, cheminformatics, statistics, computer science, or related fields.
Experience Exception: Master’s degree with 4+ years of relevant post‑degree experience (or)
PhD with no experience.
Experience in at least one programming or scripting language and at least one statistical package; R preferred.
Significant experience in at least one programming or scripting language and at least one statistical package; Python or R preferred.
Strong experience with high‑throughput sequencing data analysis.
Experience with Linux, HPC environments, version control, and workflow systems.
Compensation
St. Jude provides a reasonable estimate of the compensation range for this role: $86,320 - $154,960 per year for the Bioinformatics Research Scientist (TIRTL Collaborative Center). Specific salary offers consider skill set, experience, training, and other business factors.
St. Jude is an Equal Opportunity Employer.
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