Lead Technician, Manufacturing
LGC Group, Petaluma, CA, United States
Lead Technician, Manufacturing
The Lead Technician is responsible for executing production processes for therapeutic oligonucleotides in a cGMP-compliant facility. This role supports the manufacturing of high-quality nucleic acid-based therapeutics through hands-on operation of equipment, adherence to standard operating procedures (SOPs), and meticulous documentation practices. The lead technician works closely with cross-functional teams including Quality Assurance, Process Development, and Manufacturing Sciences and technology to ensure consistent, safe, and efficient production.
To perform this job successfully, an individual must be able to perform each of the following essential functions satisfactorily.
Oligonucleotide Production
Lead routine and non-routine operations under cGMP conditions: synthesis, cleavage and deprotection, purification, ultrafiltration and diafiltration, lyophilization, and other required chemical reactions.
Support activities related to production such as lab sanitization, material movement, and safety checks.
Equipment Operation
Operate and maintain small and large scale equipment including synthesizers, chromatography systems, and lyophilizes.
Perform instrument calibrations, preventative maintenance, and validations.
Oversee equipment readiness in alignment with scheduled production.
cGMP Compliance
Demonstrate GDP in production records, logbooks, and other required documents.
Oversee team compliance with internal standard operating procedures to ensure regulatory adherence to cGMP requirements.
Lead Quality investigations, CAPA implementations, and audit readiness.
Continuous Improvement
Lead in troubleshooting activities related to production.
Identify and execute improvement initiatives.
Provide feedback and review of systems related to operations.
Train and mentor new team members.
Cross-Functional Collaboration
Represent manufacturing in large and complex multi-department projects.
Qualifications
Minimum Qualifications:
Associate's or Bachelor's degree in Biotechnology, Chemistry, or related field
OR
3 years of experience in a cGMP chemical manufacturing role preferably oligonucleotide related.
Preferred Qualifications:
Experience with mid to large laboratory equipment and operations.
Experience operating within cGMP quality systems
Competencies & Behaviours:
Strong interpersonal and communication skills
Able to work in a fast paced and dynamic environment
Detail oriented
Able to identify, assess, and address problems efficiently
Additional Information
What we offer (US based-employees):
Competitive compensation with strong bonus program
Comprehensive medical, dental, and vision benefits for employees and dependents
FSA/HSA Pre-tax savings plans for health care, childcare, and elder care
Deductible Buffer Insurance and Critical Illness Insurance
401(k) retirement plan with matching employer contribution
Company-paid short- and long- term disability, life insurance, and employee assistance program
Flexible work options- 8, 10 and 12 hour shifts available with option of day, swing and night shifts.
Pet Insurance for our furry friends
Enhanced Parental leave of 8 additional weeks
PTO that begins immediately
Full week paid off during the holidays
Town Hall monthly meeting onsite/virtual, Cheer program where employees are recognized for outstanding work, Companywide social events, frequent catered lunches and much more!
The typical pay range for this role is:
Minimum: $24.87 Maximum: $41.46
This range represents the low and high end of the anticipated salary range for the California-based position. The actual base salary will depend on several factors such as: experience, skills, and location.
The Lead Technician is responsible for executing production processes for therapeutic oligonucleotides in a cGMP-compliant facility. This role supports the manufacturing of high-quality nucleic acid-based therapeutics through hands-on operation of equipment, adherence to standard operating procedures (SOPs), and meticulous documentation practices. The lead technician works closely with cross-functional teams including Quality Assurance, Process Development, and Manufacturing Sciences and technology to ensure consistent, safe, and efficient production.
To perform this job successfully, an individual must be able to perform each of the following essential functions satisfactorily.
Oligonucleotide Production
Lead routine and non-routine operations under cGMP conditions: synthesis, cleavage and deprotection, purification, ultrafiltration and diafiltration, lyophilization, and other required chemical reactions.
Support activities related to production such as lab sanitization, material movement, and safety checks.
Equipment Operation
Operate and maintain small and large scale equipment including synthesizers, chromatography systems, and lyophilizes.
Perform instrument calibrations, preventative maintenance, and validations.
Oversee equipment readiness in alignment with scheduled production.
cGMP Compliance
Demonstrate GDP in production records, logbooks, and other required documents.
Oversee team compliance with internal standard operating procedures to ensure regulatory adherence to cGMP requirements.
Lead Quality investigations, CAPA implementations, and audit readiness.
Continuous Improvement
Lead in troubleshooting activities related to production.
Identify and execute improvement initiatives.
Provide feedback and review of systems related to operations.
Train and mentor new team members.
Cross-Functional Collaboration
Represent manufacturing in large and complex multi-department projects.
Qualifications
Minimum Qualifications:
Associate's or Bachelor's degree in Biotechnology, Chemistry, or related field
OR
3 years of experience in a cGMP chemical manufacturing role preferably oligonucleotide related.
Preferred Qualifications:
Experience with mid to large laboratory equipment and operations.
Experience operating within cGMP quality systems
Competencies & Behaviours:
Strong interpersonal and communication skills
Able to work in a fast paced and dynamic environment
Detail oriented
Able to identify, assess, and address problems efficiently
Additional Information
What we offer (US based-employees):
Competitive compensation with strong bonus program
Comprehensive medical, dental, and vision benefits for employees and dependents
FSA/HSA Pre-tax savings plans for health care, childcare, and elder care
Deductible Buffer Insurance and Critical Illness Insurance
401(k) retirement plan with matching employer contribution
Company-paid short- and long- term disability, life insurance, and employee assistance program
Flexible work options- 8, 10 and 12 hour shifts available with option of day, swing and night shifts.
Pet Insurance for our furry friends
Enhanced Parental leave of 8 additional weeks
PTO that begins immediately
Full week paid off during the holidays
Town Hall monthly meeting onsite/virtual, Cheer program where employees are recognized for outstanding work, Companywide social events, frequent catered lunches and much more!
The typical pay range for this role is:
Minimum: $24.87 Maximum: $41.46
This range represents the low and high end of the anticipated salary range for the California-based position. The actual base salary will depend on several factors such as: experience, skills, and location.