Associate Principal Scientist, Immunology Biomarker Lead, Translational Medicine
MSD Malaysia, Cambridge, MA, United States
**Job Description****Translational Clinical Biomarkers** shapes the strategic use of clinical biomarkers to support decision-making across the development lifecycle for all therapeutic areas at our Company’s Research Laboratories. We are seeking a highly motivated **Associate Principal Scientist** to serve as an **Immunology Biomarker Lead** who will partner across functions to develop and execute biomarker strategies that connect drug mechanism, patient biology, and clinical endpoints across immune-mediated and inflammatory diseases.
The role requires a scientist who brings scientific expertise, decision-focused thinking, and strong collaboration to support biomarker hypotheses, plans, and readouts tied to development decisions in a fast-moving matrixed environment.
The individual will have the following responsibilities:* Support development and alignment of biomarker strategies for early- and late-stage clinical programs, emphasizing clear hypotheses, fit-for-purpose readouts, and decision-linked plans.* Lead biomarker sub-teams within cross-functional development program teams and represent the biomarker perspective in selected governance or program interactions.* Build alignment across stakeholders with diverse technical backgrounds and priorities to converge on pragmatic biomarker choices, tradeoffs, and recommendations.* Partner with subject matter experts to translate disease biology and drug mechanism into clinical-stage biomarker plans that address key program questions.* Support selection of fit-for-purpose biomarker technologies and methodologies such as immune profiling, omics, tissue-based readouts, and digital pathology, grounded in disease biology and therapeutic mechanism of action.* Contribute to biomarker analysis planning, data interpretation, and communication to ensure conclusions are scientifically rigorous, clinically meaningful, and clearly linked to program decisions.* Integrate fluid- and tissue-based biomarker data, in partnership with subject matter experts, to connect biomarker readouts with clinical endpoints and support decision-making.* Contribute to precision medicine and patient stratification considerations where biomarker data may inform responder biology, enrichment hypotheses, or future diagnostic optionality.**Position Qualifications**
**Education Minimum Requirement**
PhD or MD/PhD in a life sciences discipline such as Immunology, Molecular Pathology, Cell Biology, Translational Medicine, Pharmacology, Genetics/Genomics, Bioengineering, or related STEM field. MS or BS considered with equivalent experience.
**Required Experience and Skills*** PhD or MD/PhD with 5+ years, MS with 8+ years, or BS with 12+ years of experience in the biotech or pharmaceutical industry, preferably in translational or biomarker sciences.* Experience contributing to biomarker strategies for clinical development programs, including biomarker selection, sample planning, data interpretation, and decision-focused communication.* Demonstrated ability to lead through influence in matrixed environments, including working across clinical, translational, biomarker, data science, and operational stakeholders.* Strong knowledge of immune-mediated and inflammatory disease biology and clinical development, with experience in at least one of the following areas: gastrointestinal/mucosal inflammation, rheumatology, or dermatology.* Experience applying biomarkers to assess drug activity, mechanism of action, pharmacodynamic response, or patient response.* Strong analytical, problem-solving, and communication skills, with the ability to synthesize complex or ambiguous information into clear options and recommendations.**Preferred Qualifications*** Experience with fluid- and/or tissue-based biomarker readouts and their relationship to clinical endpoints.* Working knowledge of biomarker platforms and multi-modal data types, including immunoassays, flow or immune profiling, NGS, transcriptomics, proteomics, or digital pathology.* Experience partnering with bioinformatics, biostatistics, clinical, translational, and operational teams to support biomarker analysis and interpretation.* Familiarity with precision medicine concepts, patient stratification, or diagnostic considerations in clinical biomarker planning.* Experience contributing to external scientific engagement, including publications, presentations, KOL interactions, or consortia participation.#EligibleforERP**Required Skills:**Allergy and Immunology, Biomarker Analysis, Biomarker Assay Development, Biomarker Development, Biomarker Identification, Biomarker Qualification, Biomarker Research, Biomarkers, Clinical Immunology, Immunoassays, Immunology, Immunology Research, Relationship Building, Stakeholder Engagement, Translational Medicine**Preferred Skills:**Current Employees applyCurrent Contingent Workers apply**US and Puerto Rico Residents Only:**Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please
if you need an accommodation during the application or hiring process.As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.
As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.
For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.**U.S. Hybrid Work Model**Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.The salary range for this role is$129,000.00 - $203,100.00This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.We offer a comprehensive package of benefits.
Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about
#J-18808-Ljbffr
The role requires a scientist who brings scientific expertise, decision-focused thinking, and strong collaboration to support biomarker hypotheses, plans, and readouts tied to development decisions in a fast-moving matrixed environment.
The individual will have the following responsibilities:* Support development and alignment of biomarker strategies for early- and late-stage clinical programs, emphasizing clear hypotheses, fit-for-purpose readouts, and decision-linked plans.* Lead biomarker sub-teams within cross-functional development program teams and represent the biomarker perspective in selected governance or program interactions.* Build alignment across stakeholders with diverse technical backgrounds and priorities to converge on pragmatic biomarker choices, tradeoffs, and recommendations.* Partner with subject matter experts to translate disease biology and drug mechanism into clinical-stage biomarker plans that address key program questions.* Support selection of fit-for-purpose biomarker technologies and methodologies such as immune profiling, omics, tissue-based readouts, and digital pathology, grounded in disease biology and therapeutic mechanism of action.* Contribute to biomarker analysis planning, data interpretation, and communication to ensure conclusions are scientifically rigorous, clinically meaningful, and clearly linked to program decisions.* Integrate fluid- and tissue-based biomarker data, in partnership with subject matter experts, to connect biomarker readouts with clinical endpoints and support decision-making.* Contribute to precision medicine and patient stratification considerations where biomarker data may inform responder biology, enrichment hypotheses, or future diagnostic optionality.**Position Qualifications**
**Education Minimum Requirement**
PhD or MD/PhD in a life sciences discipline such as Immunology, Molecular Pathology, Cell Biology, Translational Medicine, Pharmacology, Genetics/Genomics, Bioengineering, or related STEM field. MS or BS considered with equivalent experience.
**Required Experience and Skills*** PhD or MD/PhD with 5+ years, MS with 8+ years, or BS with 12+ years of experience in the biotech or pharmaceutical industry, preferably in translational or biomarker sciences.* Experience contributing to biomarker strategies for clinical development programs, including biomarker selection, sample planning, data interpretation, and decision-focused communication.* Demonstrated ability to lead through influence in matrixed environments, including working across clinical, translational, biomarker, data science, and operational stakeholders.* Strong knowledge of immune-mediated and inflammatory disease biology and clinical development, with experience in at least one of the following areas: gastrointestinal/mucosal inflammation, rheumatology, or dermatology.* Experience applying biomarkers to assess drug activity, mechanism of action, pharmacodynamic response, or patient response.* Strong analytical, problem-solving, and communication skills, with the ability to synthesize complex or ambiguous information into clear options and recommendations.**Preferred Qualifications*** Experience with fluid- and/or tissue-based biomarker readouts and their relationship to clinical endpoints.* Working knowledge of biomarker platforms and multi-modal data types, including immunoassays, flow or immune profiling, NGS, transcriptomics, proteomics, or digital pathology.* Experience partnering with bioinformatics, biostatistics, clinical, translational, and operational teams to support biomarker analysis and interpretation.* Familiarity with precision medicine concepts, patient stratification, or diagnostic considerations in clinical biomarker planning.* Experience contributing to external scientific engagement, including publications, presentations, KOL interactions, or consortia participation.#EligibleforERP**Required Skills:**Allergy and Immunology, Biomarker Analysis, Biomarker Assay Development, Biomarker Development, Biomarker Identification, Biomarker Qualification, Biomarker Research, Biomarkers, Clinical Immunology, Immunoassays, Immunology, Immunology Research, Relationship Building, Stakeholder Engagement, Translational Medicine**Preferred Skills:**Current Employees applyCurrent Contingent Workers apply**US and Puerto Rico Residents Only:**Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please
if you need an accommodation during the application or hiring process.As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.
As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.
For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.**U.S. Hybrid Work Model**Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.The salary range for this role is$129,000.00 - $203,100.00This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.We offer a comprehensive package of benefits.
Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about
#J-18808-Ljbffr