Scientist I, Assay Development in vitro/in vivo Pharmacology
Editas Medicine, Cambridge, MA, United States
Decoding The Role:
Editas Medicine is seeking an accomplished Scientist to join our In Vivo Discovery Team to bolster our assay development group and support our pharmacology efforts. The Sci I will be integral to pipeline development by centralizing our molecular/biochemical assay development activities in support of existing targets, and spearheading research, onboarding and qualification of new assays to support new indications.
Characterizing Your Impact:
Generate high quality and reproducible data that will allow us to conclusively determine whether a disease program will move forward to the next stage of development.
Be an integral contributor to the evaluation of novel therapeutic targets and help expand Editas drug pipeline
Design, optimize and qualify assays to quantify the functional impact of therapeutic gene editing in vivo and in vitro.
Examine gene and protein expression in vivo and in vitro
Complete timely experimental documentation and reports
Demonstrate command of our standard lab techniques, instrumentation and software
Show good organization and sharing of data at group meetings
Demonstrate successful and independent troubleshooting of assay development
Maintain mammalian cell cultures and contribute to the development of in vitro disease models
The Ideal Transcript:
To thrive in this role, you’ll need:
Qualifications
B.S. w/ 6+ years, M.S. w/ 4+ years of experience or Ph.D. in cell biology, molecular biology, bioengineering, or a related field
Industry experience in molecular biology or a related field is highly desirable
Extensive experience in biochemical and cell-based assay development including design, execution and qualification.
Extensive experience in molecular and cell biology techniques: ELISA, Western blotting, MSD, flow cytometry, RT-ddPCR, quantitative PCR, biochemical/cell-based assays to measure metabolites and enzymatic activity (colorimetric, fluorometric and luminescence-based).
Extensive experience in mammalian cell culture and transfections
Experience working with CRISPR, non-viral (LNP) and/or viral (AAV, lentivirus) delivery vectors is a plus
Familiarity with DNA analysis software such as VectorNTI,Geneious,Benchlingis a plus
Fundamentals That Set You Apart
Knowledge of genetic diseases, gene-editing and gene therapy
Experience with in vitro or in vivo pharmacology and assay qualification
Experience with primary hepatocytes and advanced in vitro hepatocyte culture such as 3D-organoid culture or liver-on-a-chip
An ability to work in a dynamic, fast-paced, team-oriented, and multidisciplinary environment
Self-motivated and results-driven with excellent attention to detail
Ability to independently design, execute and evaluate protocols to drive assignments to completion
Well-organized and excellent at multi-tasking
Editas provides a comprehensive array of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Disability Insurance, Dependent Care Account, Tuition Reimbursement, 401(k) plan with company match, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy.
Salary Range:
$132,000 - $145,000
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Editas Medicine is seeking an accomplished Scientist to join our In Vivo Discovery Team to bolster our assay development group and support our pharmacology efforts. The Sci I will be integral to pipeline development by centralizing our molecular/biochemical assay development activities in support of existing targets, and spearheading research, onboarding and qualification of new assays to support new indications.
Characterizing Your Impact:
Generate high quality and reproducible data that will allow us to conclusively determine whether a disease program will move forward to the next stage of development.
Be an integral contributor to the evaluation of novel therapeutic targets and help expand Editas drug pipeline
Design, optimize and qualify assays to quantify the functional impact of therapeutic gene editing in vivo and in vitro.
Examine gene and protein expression in vivo and in vitro
Complete timely experimental documentation and reports
Demonstrate command of our standard lab techniques, instrumentation and software
Show good organization and sharing of data at group meetings
Demonstrate successful and independent troubleshooting of assay development
Maintain mammalian cell cultures and contribute to the development of in vitro disease models
The Ideal Transcript:
To thrive in this role, you’ll need:
Qualifications
B.S. w/ 6+ years, M.S. w/ 4+ years of experience or Ph.D. in cell biology, molecular biology, bioengineering, or a related field
Industry experience in molecular biology or a related field is highly desirable
Extensive experience in biochemical and cell-based assay development including design, execution and qualification.
Extensive experience in molecular and cell biology techniques: ELISA, Western blotting, MSD, flow cytometry, RT-ddPCR, quantitative PCR, biochemical/cell-based assays to measure metabolites and enzymatic activity (colorimetric, fluorometric and luminescence-based).
Extensive experience in mammalian cell culture and transfections
Experience working with CRISPR, non-viral (LNP) and/or viral (AAV, lentivirus) delivery vectors is a plus
Familiarity with DNA analysis software such as VectorNTI,Geneious,Benchlingis a plus
Fundamentals That Set You Apart
Knowledge of genetic diseases, gene-editing and gene therapy
Experience with in vitro or in vivo pharmacology and assay qualification
Experience with primary hepatocytes and advanced in vitro hepatocyte culture such as 3D-organoid culture or liver-on-a-chip
An ability to work in a dynamic, fast-paced, team-oriented, and multidisciplinary environment
Self-motivated and results-driven with excellent attention to detail
Ability to independently design, execute and evaluate protocols to drive assignments to completion
Well-organized and excellent at multi-tasking
Editas provides a comprehensive array of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Disability Insurance, Dependent Care Account, Tuition Reimbursement, 401(k) plan with company match, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy.
Salary Range:
$132,000 - $145,000
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