VP, DM1 Commercial Asset Lead

Company Overview
Dyne Therapeutics focuses on delivering functional improvement for people living with genetically driven neuromuscular diseases. The company develops therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. Clinical programs are advancing for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1), while preclinical programmes target facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. Dyne’s mission is to deliver functional improvement for individuals, families and communities.

Role Summary
The VP, DM1 Commercial Asset Lead (CAL) leads the value of Dyne’s DM1 commercial asset from a global perspective, developing and implementing strategies that maximize reach and value creation within the neuromuscular portfolio. The CAL conducts market analysis, competitive positioning, launch readiness and lifecycle management to support long‑term success in bringing the asset to patients worldwide. As a key member of the Program Team, the CAL collaborates cross‑functionally to shape program strategy and drive global launch planning, beginning with the U.S.

Primary Responsibilities
Global Commercial Strategy & Asset Leadership

Define global asset commercialization strategy and plan to achieve milestones and timelines for successful launches.

Shape competitive positioning, differentiation strategy, and overall value proposition.

Provide commercialization input into program strategy, including label and access considerations.

Establish strategic imperatives, critical success factors, and execution priorities.

Launch Readiness & Market Planning

Lead global launch planning and readiness across key markets, starting with the U.S.

Partner with cross‑functional teams (medical, regulatory, supply, marketing, digital, data) to prepare for launch execution.

Collaborate with affiliate teams and external partners to support reimbursement and access readiness.

Drive continuous improvement and learning across markets.

Cross‑Functional Leadership & Program Integration

Serve as a key member of the Program Team and lead the DM1 Commercial Sub‑Team.

Ensure alignment across commercialization pillars (product profile, access, launch planning).

Facilitate cross‑functional decision‑making and drive timely outcomes.

Build strong partnerships across functions and maintain clear communication with leadership.

External Engagement & Stakeholder Management

Build a credible and visible presence within the DM1 community, including KOLs, patient advocacy groups, and care teams.

Maintain awareness of competitive landscape and evolving market dynamics.

Support preparation and presentation of commercialization materials for senior leadership and Board discussions.

Participate in business development activities, including opportunity evaluation and due diligence, as needed.

Education and Skills Requirements

Bachelor’s degree in a relevant scientific, medical, or business discipline required; advanced degree strongly preferred.

Minimum of 20 years of experience in the biopharmaceutical industry.

15+ years of commercialization and cross‑functional leadership experience.

Extensive experience leading global product launches, including a minimum of 3 launches.

Rare disease experience strongly preferred; neuromuscular experience highly advantageous.

Proven track record of delivering on business objectives in fast‑paced, high‑stakes environments.

Proven ability to steer assets from late‑stage development through approval and launch.

Experience influencing global and U.S. market access and reimbursement readiness.

Demonstrated success developing global commercialization strategies.

Experience collaborating across clinical, medical, regulatory, supply, and commercial functions.

Ability to synthesize complex data to guide strategy.

Strong cross‑functional leadership and stakeholder influence.

Proven ability to inspire and mobilize high‑performing teams.

Exceptional communication and stakeholder engagement skills.

Ability to build strong external relationships (KOLs, advocacy, payers, regulators).

Comfortable leading through ambiguity and change.

High integrity and strong patient‑centric mindset.

Strong sense of urgency and ability to prioritize effectively.

Pay Range
$272,000 – $340,000 USD

Additional Information
The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all‑inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

Equal Opportunity Employer
Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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