VP, DM1 Commercial Asset Lead

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease.

Role Summary
The VP, DM1 Commercial Asset Lead (CAL) is a passionate driver of the value of Dyne’s DM1 commercial asset with a global perspective, bringing adaptable leadership to develop and implement commercialization strategies that maximize reach and value creation within the neuromuscular portfolio. This mandate includes market analysis, competitive positioning, launch readiness and execution, and input into lifecycle management to support long‑term success in bringing the asset to patients globally. The CAL leads the definition of commercialization strategy, strategic imperatives, critical success factors, executional priorities, and global launch planning in close partnership with affiliate launch teams. The CAL collaborates with Program Team members, functional leads, and affiliate teams to achieve a differentiated product profile, competitive label, broad reimbursement, and successful global launches, starting with the U.S. This role is based onsite in Waltham, MA.

Primary Responsibilities

Define global asset commercialization strategy and plan to achieve milestones and timelines for successful launches

Shape competitive positioning, differentiation strategy, and overall value proposition

Provide commercialization input into program strategy, including label and access considerations

Establish strategic imperatives, critical success factors, and execution priorities

Launch Readiness & Market Planning

Lead global launch planning and readiness across key markets, starting with the U.S.

Partner with cross‑functional teams (medical, regulatory, supply, marketing, digital, data) to prepare for launch execution

Collaborate with affiliate teams and external partners to support reimbursement and access readiness

Drive continuous improvement and learning across markets

Cross‑Functional Leadership & Program Integration

Serve as a key member of the Program Team and lead the DM1 Commercial Sub‑Team

Ensure alignment across commercialization pillars (product profile, access, launch planning)

Facilitate cross‑functional decision‑making and drive timely outcomes

Build strong partnerships across functions and maintain clear communication with leadership

External Engagement & Stakeholder Management

Build a credible and visible presence within the DM1 community, including KOLs, patient advocacy groups, and care teams

Maintain awareness of competitive landscape and evolving market dynamics

Support preparation and presentation of commercialization materials for senior leadership and Board discussions

Participate in business development activities, including opportunity evaluation and due diligence, as needed

Education and Skill Requirements

Bachelor’s degree in a relevant scientific, medical, or business discipline required; advanced degree strongly preferred

Minimum of 20 years of experience in the biopharmaceutical industry

15+ years of commercialization and cross‑functional leadership experience

Extensive experience leading global product launches, including a minimum of 3 launches

Rare disease experience strongly preferred; neuromuscular experience highly advantageous

Proven track record of delivering on business objectives in fast‑paced, high‑stakes environments

Proven ability to steer assets from late‑stage development through approval and launch

Experience influencing global and U.S. market access and reimbursement readiness

Demonstrated success developing global commercialization strategies

Experience collaborating across clinical, medical, regulatory, supply, and commercial functions

Ability to synthesize complex data to guide strategy

Strong cross‑functional leadership and stakeholder influence

Proven ability to inspire and mobilize high‑performing teams

Exceptional communication and stakeholder engagement skills

Ability to build strong external relationships (KOLs, advocacy, payers, regulators)

Comfortable leading through ambiguity and change

High integrity and strong patient‑centric mindset

Strong sense of urgency and ability to prioritize effectively

Pay Range: $272,000 - $340,000 USD

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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