Research Associate II-III IN VIVO
Calidi Biotherapeutics, San Diego, CA, United States
Calidi Biotherapeutics is a clinical-stage immuno-oncology company with proprietary technology that is revolutionizing the utilization of oncolytic viruses through an allogeneic cell-based delivery system. Calidi Biotherapeutics is advancing this potent stem cell and oncolytic virus combination for use in multiple difficult-to-treat oncology indications. Our team is also developing a universal cell delivery system to protect, amplify and potentiate oncolytic viruses currently in development.
GENERAL PURPOSE OF JOB:
Performs research and/or development in collaboration with others for projects. Makes detailed observations, analyzes data and interprets results. Research involves the use of oncolytic viruses, tumor biopsies, murine and human cells cell lines, experimental cancer model tissues, and blood from cancer patients and healthy donors.
ESSENTIAL DUTIES AND RESPONSIBILITIES:
Performs in vivo studies to evaluate efficacy in murine models
Administraters test substances by various routes (i.e., intratumoral, IP, IV, SC, PO, topical, etc.)
Performs mouse necropsies, tissue harvest, and mouse blood collection via: cardiac puncture, submandibular, retro orbital etc.),
Performs in vivo imaging to monitor tumor growth (IVIS or equivalent).
Manages and observes animals for general health and overall well-being
Adheres to SOPs to ensure study integrity and quality
Performs routine maintenance and propagation of established cell lines
Collaborates with research teams on molecular cloning, qPCR, Flow cytometry, ELISA, IHC.
Maintains accurate experiment records in various internal databases and perform basic data analysis
Adheres to good health and safety practices and compliance with applicable EH&S rules and participating in mandatory safety training programs
Independently performs all methods and conduct all study types commonly employed by the team
Other duties as needed
EDUCATION and/or EXPERIENCE:
B.S. or higher in life science, or related field
3+ years of experience animal laboratory setting
Current knowledge of pre-clinical tumor models, animal handling and dosing.
Strong hands-on experience with animal handling, dosing (Intratumoral, IP, IV, PO, and SC), bleeding, necropsy and tissue harvest
Experience in cell culture, immuno-oncology, TILS isolation, and flow cytometry is a plus.
Good organizational and documentation skills
Dedication to working in a team-oriented environment to contribute to shared project
Strong work ethic, self-motivation, and ability to multi-task in a fast-paced work environment
Excellent communication skills with ability to effectively communicate with other research teams
Strong knowledge of MS Word, Outlook, PowerPoint, Excel.
Perform other duties as directed by Management
MATHEMATICAL SKILLS:
Ability to work with mathematical concepts such as calculation of dilutions and statistical analyses.
Ability to apply concepts such as fractions, percentages, ratios, and proportions to practical situations.
REASONING ABILITY:
Ability to define problems, collect data, establish facts, and draw valid conclusions.
LANGUAGE SKILLS:
Excellent communication skills with ability to effectively communicate with other research teams
Ability to read and understand technical procedures
Ability to write protocols and reports
Ability to effectively present data and respond to questions from co-workers
The PERKS:
Competitive Total Rewards package (Medical, Dental, Vision, 401k Safe Harbor Match) offered to full-time employees
WORK LOCATION:
Calidi Biotherapeutics employment provides the opportunity to work in beautiful San Diego, California only minutes from the nearest beach.
EOE and Accommodation:
We value diversity and are proud to be an Equal Opportunity and Aff…
Notice to Agency and Search Firm Representatives
Calidi Biotherapeutics is not accepting unsolicited resumes from agencies and/or search firms for this job posting. Resumes submitted to any Calidi Biotherapeutics employee by a third-party agency and/or search firm without a valid written & signed search agreement, will become the sole property of Calidi Biotherapeutics. No fee will be paid if a candidate is hired for this position as a result of an unsolicited agency or search firm referral.
EMPLOYER’S RIGHTS:
This job description does not list all the duties of the job. You may be asked by supervisors or managers to perform other duties. You will be evaluated in part based upon your performance of the tasks listed in this job description.
The employer has the right to revise this job description at any time. The job description is not a contract for employment, and either you or the employer may terminate employment at any time, for any reason.
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GENERAL PURPOSE OF JOB:
Performs research and/or development in collaboration with others for projects. Makes detailed observations, analyzes data and interprets results. Research involves the use of oncolytic viruses, tumor biopsies, murine and human cells cell lines, experimental cancer model tissues, and blood from cancer patients and healthy donors.
ESSENTIAL DUTIES AND RESPONSIBILITIES:
Performs in vivo studies to evaluate efficacy in murine models
Administraters test substances by various routes (i.e., intratumoral, IP, IV, SC, PO, topical, etc.)
Performs mouse necropsies, tissue harvest, and mouse blood collection via: cardiac puncture, submandibular, retro orbital etc.),
Performs in vivo imaging to monitor tumor growth (IVIS or equivalent).
Manages and observes animals for general health and overall well-being
Adheres to SOPs to ensure study integrity and quality
Performs routine maintenance and propagation of established cell lines
Collaborates with research teams on molecular cloning, qPCR, Flow cytometry, ELISA, IHC.
Maintains accurate experiment records in various internal databases and perform basic data analysis
Adheres to good health and safety practices and compliance with applicable EH&S rules and participating in mandatory safety training programs
Independently performs all methods and conduct all study types commonly employed by the team
Other duties as needed
EDUCATION and/or EXPERIENCE:
B.S. or higher in life science, or related field
3+ years of experience animal laboratory setting
Current knowledge of pre-clinical tumor models, animal handling and dosing.
Strong hands-on experience with animal handling, dosing (Intratumoral, IP, IV, PO, and SC), bleeding, necropsy and tissue harvest
Experience in cell culture, immuno-oncology, TILS isolation, and flow cytometry is a plus.
Good organizational and documentation skills
Dedication to working in a team-oriented environment to contribute to shared project
Strong work ethic, self-motivation, and ability to multi-task in a fast-paced work environment
Excellent communication skills with ability to effectively communicate with other research teams
Strong knowledge of MS Word, Outlook, PowerPoint, Excel.
Perform other duties as directed by Management
MATHEMATICAL SKILLS:
Ability to work with mathematical concepts such as calculation of dilutions and statistical analyses.
Ability to apply concepts such as fractions, percentages, ratios, and proportions to practical situations.
REASONING ABILITY:
Ability to define problems, collect data, establish facts, and draw valid conclusions.
LANGUAGE SKILLS:
Excellent communication skills with ability to effectively communicate with other research teams
Ability to read and understand technical procedures
Ability to write protocols and reports
Ability to effectively present data and respond to questions from co-workers
The PERKS:
Competitive Total Rewards package (Medical, Dental, Vision, 401k Safe Harbor Match) offered to full-time employees
WORK LOCATION:
Calidi Biotherapeutics employment provides the opportunity to work in beautiful San Diego, California only minutes from the nearest beach.
EOE and Accommodation:
We value diversity and are proud to be an Equal Opportunity and Aff…
Notice to Agency and Search Firm Representatives
Calidi Biotherapeutics is not accepting unsolicited resumes from agencies and/or search firms for this job posting. Resumes submitted to any Calidi Biotherapeutics employee by a third-party agency and/or search firm without a valid written & signed search agreement, will become the sole property of Calidi Biotherapeutics. No fee will be paid if a candidate is hired for this position as a result of an unsolicited agency or search firm referral.
EMPLOYER’S RIGHTS:
This job description does not list all the duties of the job. You may be asked by supervisors or managers to perform other duties. You will be evaluated in part based upon your performance of the tasks listed in this job description.
The employer has the right to revise this job description at any time. The job description is not a contract for employment, and either you or the employer may terminate employment at any time, for any reason.
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