According to his wife, Cory, Charles died peacefully at his home in Santa Fe, New Mexico.
Charles was diagnosed with stage 4 bladder cancer in 2009 and took a leave of absence from calling boxing fights on Showtime. Thanks to HBO, Charles had a chance to call one last fight in March, working alongside Bob Papa on Boxing After Dark.
Born Nicholas Charles Nickeas in Chicago, Charles graduated from Columbia College Chicago. Before arriving at CNN in 1980, Charles worked in Washington D.C. and Baltimore.