How many profiles should you follow on Twitter? Fast answer: as many as you can honestly manage.
There is no universal magic Twitter following figure that everybody needs to observe or should strive to meet. It’s entirely up to you. You should follow as many users as you find comfortable. And it’s important that you’re honest about this number, and that you aren’t simply following profiles because you feel it’s something you should do, or because you’re hoping that they will follow you back, because this isn’t how Twitter works. In fact, behaving in this way is counter-productive to enjoyment.
Follow too many people on Twitter and one or two things will happen:
1. Because of the sheer volume of tweets you’ll be forced to ignore many of them (or will simply miss their updates)
2. Twitter will be completely ruined for you